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经验公式(希尔记法):
C14H14FN3O2S
化学文摘社编号:
分子量:
307.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
CLP257, ≥98% (HPLC)
InChI
1S/C14H14FN3O2S/c15-10-4-3-9(11(19)8-10)7-12-13(20)17-14(21-12)18-6-2-1-5-16-18/h3-4,7-8,16,19H,1-2,5-6H2/b12-7-
SMILES string
O=C1/C(SC(N2CCCCN2)=N1)=C/C3=CC=C(F)C=C3O
InChI key
SKCADXVKQRCWTR-GHXNOFRVSA-N
assay
≥98% (HPLC)
form
powder
color
, white to yellow to light brown
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Quality Level
相关类别
Application
CLP257已被用作人类神经元培养物中的K+- Cl- 共转运蛋白2(KCC2)增强剂。
Biochem/physiol Actions
CLP257是一种选择性的K+-Cl−共转运蛋白KCC2激活剂,可恢复KCC2活性降低的神经元中受损的Cl−转运。 显然,CLP257在翻译后调节血浆中的KCC2蛋白更新。
CLP257是选择性K+-Cl−共转运蛋白KCC2激活剂。
在链脲佐菌素治疗的大鼠中,通过激活精氨酸-加压素神经元中的K+- Cl- 共转运蛋白2(KCC2),CLP257介导γ-氨基丁酸(GABA)能激发。但是,它对KCC1,KCC3和KCC4无效。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Young-Beom Kim et al.
Diabetes, 67(3), 486-495 (2017-12-08)
Diabetes mellitus (DM) is associated with increased plasma levels of arginine-vasopressin (AVP), which may aggravate hyperglycemia and nephropathy. However, the mechanisms by which DM may cause the increased AVP levels are not known. Electrophysiological recordings in supraoptic nucleus (SON) slices
Aaron J Barbour et al.
Neurobiology of disease, 141, 104878-104878 (2020-04-29)
Approximately half of people infected with HIV (PWH) exhibit HIV-associated neuropathology (neuroHIV), even when receiving combined antiretroviral therapy. Opiate use is widespread in PWH and exacerbates neuroHIV. While neurons themselves are not infected, they incur sublethal damage and GABAergic disruption
Martin Gagnon et al.
Nature medicine, 19(11), 1524-1528 (2013-10-08)
The K(+)-Cl(-) cotransporter KCC2 is responsible for maintaining low Cl(-) concentration in neurons of the central nervous system (CNS), which is essential for postsynaptic inhibition through GABA(A) and glycine receptors. Although no CNS disorders have been associated with KCC2 mutations
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