SML1368
CLP257
≥98% (HPLC)
别名:
(5Z)-5-[(4-氟代-2-羟基苯基)亚甲基]-2-(四氢-1-(2H)-哒嗪基)-4(5H)-噻唑酮
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关于此项目
经验公式(希尔记法):
C14H14FN3O2S
化学文摘社编号:
分子量:
307.34
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
, white to yellow to light brown
溶解性
DMSO: 20 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C1/C(SC(N2CCCCN2)=N1)=C/C3=CC=C(F)C=C3O
InChI
1S/C14H14FN3O2S/c15-10-4-3-9(11(19)8-10)7-12-13(20)17-14(21-12)18-6-2-1-5-16-18/h3-4,7-8,16,19H,1-2,5-6H2/b12-7-
InChI key
SKCADXVKQRCWTR-GHXNOFRVSA-N
相关类别
应用
CLP257已被用作人类神经元培养物中的K+- Cl- 共转运蛋白2(KCC2)增强剂。
生化/生理作用
CLP257是一种选择性的K+-Cl−共转运蛋白KCC2激活剂,可恢复KCC2活性降低的神经元中受损的Cl−转运。 显然,CLP257在翻译后调节血浆中的KCC2蛋白更新。
CLP257是选择性K+-Cl−共转运蛋白KCC2激活剂。
在链脲佐菌素治疗的大鼠中,通过激活精氨酸-加压素神经元中的K+- Cl- 共转运蛋白2(KCC2),CLP257介导γ-氨基丁酸(GABA)能激发。但是,它对KCC1,KCC3和KCC4无效。
警示用语:
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Aaron J Barbour et al.
Neurobiology of disease, 141, 104878-104878 (2020-04-29)
Approximately half of people infected with HIV (PWH) exhibit HIV-associated neuropathology (neuroHIV), even when receiving combined antiretroviral therapy. Opiate use is widespread in PWH and exacerbates neuroHIV. While neurons themselves are not infected, they incur sublethal damage and GABAergic disruption
Young-Beom Kim et al.
Diabetes, 67(3), 486-495 (2017-12-08)
Diabetes mellitus (DM) is associated with increased plasma levels of arginine-vasopressin (AVP), which may aggravate hyperglycemia and nephropathy. However, the mechanisms by which DM may cause the increased AVP levels are not known. Electrophysiological recordings in supraoptic nucleus (SON) slices
Martin Gagnon et al.
Nature medicine, 19(11), 1524-1528 (2013-10-08)
The K(+)-Cl(-) cotransporter KCC2 is responsible for maintaining low Cl(-) concentration in neurons of the central nervous system (CNS), which is essential for postsynaptic inhibition through GABA(A) and glycine receptors. Although no CNS disorders have been associated with KCC2 mutations
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