SML1447
克立咪唑 盐酸盐
≥98% (HPLC)
别名:
1-对氯苄基-2-(1-吡咯烷基)甲基苯并咪唑 盐酸盐
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 2 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
ClC(C=C1)=CC=C1CN2C(CN3CCCC3)=NC4=CC=CC=C42.[H]Cl
InChI
1S/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H
InChI key
DNFMJYXRIMLMBZ-UHFFFAOYSA-N
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一般描述
Clemizole is a potent anti-allergic drug.
生化/生理作用
Clemizole is a potent and preferring inhibitor of TRPC5 that efficiently blocks heterologously expressed homomeric TRPC5 channels as well as heteromeric TRPC1:TRPC5 channels. Clemizole is a potent and selective H1 histamine receptor antagonist. Clemizole inhibited binding of HCV RNA by NS4B inhibit HCV RNA replication in cell culture.
Clemizole is a potent and preferring inhibitor of TRPC5; Antihistaminic.
Clemizole is an antihistamine and an inhibitor of NS4B (nonstructural protein 4B) RNA of HCV (hepatitis C virus). Studies in Scn1α (sodium channel, voltage-gated, type I, α) Zebrafish mutant show that this drug has the potential as a therapeutic agent in Dravet Syndrome treatment.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Clemizole hydrochloride.
Parvez M
Acta Crystallographica Section C, Structural Chemistry, 52(4), 904-905 (1996)
Caoimhin S Griffin et al.
Scientific reports, 8(1), 9264-9264 (2018-06-20)
Acetylcholine contracts the bladder by binding to muscarinic M3 receptors on the detrusor, leading to Ca2+ influx via voltage-gated Ca2+ channels. The cellular mechanisms linking these events are poorly understood, but studies have suggested that activation of TRPC4 channels could
Scott C Baraban et al.
Nature communications, 4, 2410-2410 (2013-09-05)
Dravet syndrome is a catastrophic pediatric epilepsy with severe intellectual disability, impaired social development and persistent drug-resistant seizures. One of its primary monogenic causes are mutations in Nav1.1 (SCN1A), a voltage-gated sodium channel. Here we characterize zebrafish Nav1.1 (scn1Lab) mutants
Alberto Arboit et al.
Cells, 9(2) (2020-02-09)
Persistent neural activity has been observed in vivo during working memory tasks, and supports short-term (up to tens of seconds) retention of information. While synaptic and intrinsic cellular mechanisms of persistent firing have been proposed, underlying cellular mechanisms are not
Julia M Richter et al.
Molecular pharmacology, 86(5), 514-521 (2014-08-21)
Canonical transient receptor potential channel 5 (TRPC5) is a nonselective, Ca(2+)-permeable cation channel that belongs to the large family of transient receptor potential channels. It is predominantly found in the central nervous system with a high expression density in the
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