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Merck
CN

SML1575

环孢菌素H

From Tolypocladium inflatum, ≥97% (HPLC), lentiviral transduction enhancer, powder

别名:

1,4,7,10,13,16,19,22,25,28,31-十一碳氮杂环三金刚烷，环肽衍生物, 5-（N-甲基-D-缬氨酸）-环孢菌素A

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选择尺寸

关于此项目

经验公式（希尔记法）:
C62H111N11O12
化学文摘社编号:
83602-39-5
分子量:
1202.61
UNSPSC Code:
51111800
NACRES:
NA.77

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产品名称

环孢菌素H, ≥97% (HPLC)

SMILES string

N1([C@@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N(C(C(=O)N[C@H](C(=O)N(CC(=O)N([C@H](C1=O)CC(C)C)C)C)CC)[C@H](O)[C@@H](C\C=C\C)C)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)C

InChI

1S/C63H113N11O12/c1-26-28-29-41(15)53(76)52-56(79)66-44(27-2)58(81)67(18)34-49(75)68(19)46(31-36(5)6)60(83)72(23)50(39(11)12)62(85)69(20)45(30-35(3)4)55(78)64-42(16)54(77)65-43(17)57(80)70(21)47(32-37(7)8)59(82)71(22)48(33-38(9)10)61(84)73(24)51(40(13)14)63(86)74(52)25/h26,28,35-48,50-53,76H,27,29-34H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)/b28-26+/t41-,42+,43-,44+,45+,46+,47+,48+,50-,51+,52?,53-/m1/s1

InChI key

BQQHPBPTWWXRMU-SXHXJWHLSA-N

biological source

Tolypocladium inflatum

assay

≥97% (HPLC)

form

powder

optical activity

[α]/D -100 to -115°, c = 0.5 in methanol

storage condition

desiccated, protect from light

color

white to beige

storage temp.

−20°C

Quality Level

100

相关类别

Application

环孢素H已被用于：
  • 预培养用于转导的谱系缺失的小鼠 Flt3ITDIDH2R140Q BM 细胞
  • 作为甲酰肽受体（FPR）拮抗剂来研究FPR1在多形核白细胞（PMN）钙动员中的作用
  • 作为研究其对人类诱导多能干细胞（iPSC）和 T 细胞同源定向修复（HDR）编辑效率影响的小分子之一

Biochem/physiol Actions

环孢菌素 H 是中性粒细胞中甲酰肽受体 1（FPR-1）和甲酰肽诱导的超氧化物形成的选择性抑制剂。
环孢菌素 H 是中性粒细胞中甲酰肽受体 1（FPR-1）和甲酰肽诱导的超氧化物形成的选择性抑制剂。 环孢菌素 H 不结合亲环蛋白或引起免疫抑制反应。 据报道，环孢菌素 H 抑制小鼠皮肤细胞中促进肿瘤的佛波酯 TPA/PMA，并抑制钙/钙调蛋白依赖性的 EF-2 磷酸化。

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品
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分析证书(COA)

Lot/Batch Number
0000522558
0000522558
0000506056
0000506057
0000506057

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