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Merck
CN

SML1598

Bis(heptyl)-cognitin dihydrochloride

≥98% (HPLC)

别名:

9-Amino-1,2,3,4-tetrahydroacridine bis 1,7-heptylene dihydrochloride, B7C, Bis(7)-cognitin dihydrochloride, Heptylenebis-tacrine dihydrochloride, N,N′-Bis-(1,2,3,4-tetrahydro-acridin-9-yl)-heptane-1,7-diamine dihydrochloride, heptylene-bis(THA) dihydrochloride, heptylene-bis(tacrine) dihydrochloride

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关于此项目

经验公式（希尔记法）:
C33H40N4 · 2HCl
化学文摘社编号:
224445-12-9
分子量:
565.62
NACRES:
NA.25
PubChem Substance ID:
329825486
UNSPSC Code:
12352202
MDL number:
MFCD08062163

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InChI

1S/C33H40N4.2ClH/c1(2-12-22-34-32-24-14-4-8-18-28(24)36-29-19-9-5-15-25(29)32)3-13-23-35-33-26-16-6-10-20-30(26)37-31-21-11-7-17-27(31)33;;/h4,6,8,10,14,16,18,20H,1-3,5,7,9,11-13,15,17,19,21-23H2,(H,34,36)(H,35,37);2*1H

SMILES string

Cl.Cl.C(CCCNc1c2CCCCc2nc3ccccc13)CCCNc4c5CCCCc5nc6ccccc46

InChI key

RHKXINFBJWDTSK-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 10 mg/mL, clear

storage temp.

2-8°C

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Biochem/physiol Actions

Bis(heptyl)-cognitin (B7C) is a potent neuroprotective agent and cognitive enhancer. It is thought to have multiple mechanisms of action including inhibition of AChE, and inihbititon of the amyloid precursor protein/beta-amyloid cascade. It has been shown to inhibit the formation of Aβ1-42 oligomers and reduce the amount of pre-formed Aβ1-42 oligomers, and to induce robust neurite outgrowth in PC12 cells.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
046M4615V

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Ren-wen Han et al.
Brain research, 1470, 59-68 (2012-07-04)
Our previous reports indicated that bis(propyl)-cognitin (B3C) and bis(heptyl)-cognitin (B7C), as novel dimers derived from tacrine, may be potential multifunctional drugs for treating Alzheimer's disease. There is little knowledge on the cognitive function of B3C while B7C appeared to reverse
Lan Chang et al.
Scientific reports, 5, 10256-10256 (2015-07-22)
β-amyloid (Aβ) oligomers have been closely implicated in the pathogenesis of Alzheimer's disease (AD). We found, for the first time, that bis(heptyl)-cognitin, a novel dimeric acetylcholinesterase (AChE) inhibitor derived from tacrine, prevented Aβ oligomers-induced inhibition of long-term potentiation (LTP) at
Sheng-Quan Hu et al.
CNS neuroscience & therapeutics, 21(6), 520-529 (2015-04-29)
Neurodegenerative disorders are caused by progressive neuronal loss in the brain, and hence, compounds that could promote neuritogenesis may have therapeutic values. In this study, the effects of bis(heptyl)-cognitin (B7C), a multifunctional dimer, on neurite outgrowth were investigated in both

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