SML1721
维达洛芬
≥98% (HPLC)
别名:
(±)-2-(4-环己基萘-1-基)丙酸
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关于此项目
经验公式（希尔记法）:
C19H22O2
化学文摘社编号:
分子量:
282.38
EC Number:
275-196-6
UNSPSC Code:
12352200
NACRES:
NA.77
Beilstein/REAXYS Number:
5568831
MDL number:
产品名称
维达洛芬, ≥98% (HPLC)
InChI key
VZUGVMQFWFVFBX-UHFFFAOYSA-N
InChI
1S/C19H22O2/c1-13(19(20)21)15-11-12-16(14-7-3-2-4-8-14)18-10-6-5-9-17(15)18/h5-6,9-14H,2-4,7-8H2,1H3,(H,20,21)
SMILES string
CC(C(O)=O)c1ccc(C2CCCCC2)c3ccccc13
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
Quality Level
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相关类别
Biochem/physiol Actions
Vedaprofen is a non-steroidal anti-inflammatory drug (NSAID) that has been found to have antimicrobial activity. Vedaprofen is primarily used as a veterinary analgesic and anti-inflammatory for arthritis and pain. Its anti-inflammatory activity is due to cyclooxygenase inihbition, while its antimicrobial activity is less certain. Vedaprofen can kill B. subtilis by permeabilizing its membrane. Other studies have shown vedaprofen can target the Escherichia coli DNA polymerase III β subunit.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
新产品
此项目有
Denise Tabacchi Fantoni et al.
BMC veterinary research, 11, 24-24 (2015-04-17)
This prospective randomized blinded clinical study aimed to investigate the potential of vedaprofen for preventive analgesia, comparing its analgesic effects with ketoprofen administered post-operatively in dogs undergoing maxillectomy or mandibulectomy. Pain control was effective and rescue analgesia was not necessary
DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs.
Zhou Yin et al.
Chemistry & biology, 21(4), 481-487 (2014-03-19)
Evidence suggests that some nonsteroidal anti-inflammatory drugs (NSAIDs) possess antibacterial properties with an unknown mechanism. We describe the in vitro antibacterial properties of the NSAIDs carprofen, bromfenac, and vedaprofen, and show that these NSAIDs inhibit the Escherichia coli DNA polymerase III
Anne Lamsa et al.
ACS chemical biology, 11(8), 2222-2231 (2016-05-20)
Increasing antimicrobial resistance has become a major public health crisis. New antimicrobials with novel mechanisms of action (MOA) are desperately needed. We previously developed a method, bacterial cytological profiling (BCP), which utilizes fluorescence microscopy to rapidly identify the MOA of
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