SML1787
仙草素
≥98% (HPLC), powder, anti-inflammatory agent
别名:
2-（3,4-二甲氧基苯基）-5,6,7-三甲氧基铬-4-酮, 2-（3,4-二羟基苯基）-5,6,7-三羟基-4 H -1-苯并吡喃-4-酮, 3,5,6,7-五甲氧基黄酮, 6-羟基木犀草素 5,6,7,3′,4′-五甲基醚, 甜橙黄酮
产品名称
仙草素, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 3 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
O=C1C=C(C2=CC(OC)=C(OC)C=C2)OC3=C1C(OC)=C(OC)C(OC)=C3
InChI
1S/C20H20O7/c1-22-13-7-6-11(8-15(13)23-2)14-9-12(21)18-16(27-14)10-17(24-3)19(25-4)20(18)26-5/h6-10H,1-5H3
InChI key
LKMNXYDUQXAUCZ-UHFFFAOYSA-N
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一般描述
甜橙黄酮是一种植物来源的多甲氧基黄酮。主要分布于肾茶(原变种)Orthosiphon aristatus var. aristatus和各种柑橘类水果中。相比其他部位，甜橙黄酮在柑橘类水果的皮中大量存在。
应用
甜橙黄酮可作为柑橘类黄酮，研究其在棕榈酸(PA)处理HepG2细胞中通过激活AMP活化蛋白激酶(AMPK)而发挥抗成脂作用。还可作为标准品，通过超高效液相色谱法定量分析猫须草Orthosiphon stamineus提取物中的多酚含量。
生化/生理作用
甜橙黄酮是一种具有抗炎和抗增殖活性的柑桔类黄酮。它还显示出可增强脂肪生成和脂解作用。具有抗癌、抗微生物、抗痴呆、抗氧化、抗肥胖、抗锥虫和血管舒张活性。可抑制P-糖蛋白(P-gp)、外排转运蛋白和乳腺癌耐药蛋白(BCRP)。甜橙黄酮可作为黄酮类化学增敏剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Vasilis P Androutsopoulos et al.
Pharmacology & therapeutics, 126(1), 9-20 (2010-02-16)
Flavonoids are polyphenolic compounds that have attracted the attention of the scientific community as the hallmark molecules responsible for cancer prevention by a plethora of different mechanisms. One of their most important characteristics, responsible for their cancer preventive properties, is
Mirka Laavola et al.
Planta medica, 78(8), 779-786 (2012-04-21)
Cytokines and other inflammatory mediators, such as prostaglandin E₂ (PGE₂) and nitric oxide (NO) produced by cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), respectively, activate and drive inflammation and therefore serve as targets for anti-inflammatory drug development. Orthosiphon stamineus
Seong-Il Kang et al.
Biological & pharmaceutical bulletin, 38(4), 552-558 (2015-03-05)
Sinensetin is a rare polymethoxylated flavone (PMF) found in certain citrus fruits. In this study, we investigated the effects of sinensetin on lipid metabolism in 3T3-L1 cells. Sinensetin promoted adipogenesis in 3T3-L1 preadipocytes growing in incomplete differentiation medium, which did
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