SML1903
IMB5046
≥98% (HPLC)
别名:
2-(4-Morpholinyl)-5-nitro-benzoic acid [4-(methylthio)phenyl]methyl ester
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关于此项目
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(C1=C(N2CCOCC2)C=CC([N+]([O-])=O)=C1)OCC3=CC=C(SC)C=C3
InChI
1S/C19H20N2O5S/c1-27-16-5-2-14(3-6-16)13-26-19(22)17-12-15(21(23)24)4-7-18(17)20-8-10-25-11-9-20/h2-7,12H,8-11,13H2,1H3
InChI key
VPXGOSNPXCNGAI-UHFFFAOYSA-N
Biochem/physiol Actions
IMB5046 is a microtubule inhibitor that has antitumor activity, overcoming multidrug-resistance.
IMB5046 is a microtubule inhibitor that has antitumor activity, overcoming multidrug-resistance. IMB5046 was cytotoxic with an IC50 range of 37 to 426 nM against multiple tumor cell lines, including some that were resistant to colchicine, vincristine and paclitaxel. IMB5046 was also active against human lung tumor xenografts. IMB5046 was found to bind to tubulin at the colchicine site, but with a different binding mode. IMB5046 inhibited tubulin polymerization, and induced G2/M arrest.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Yan-Bo Zheng et al.
Scientific reports, 6, 31472-31472 (2016-08-12)
Multidrug resistance is a major limitation for microtubule-binding agents in cancer treatment. Here we report a novel microtubule inhibitor (2-morpholin-4-yl-5-nitro-benzoic acid 4-methylsulfanyl-benzyl ester, IMB5046), its cytotoxicity against multidrug-resistant cell lines and its antitumor efficacy in animal models. IMB5046 disrupted microtubule
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML1903-5MG | 04061833265543 |
| SML1903-25MG | 04061833265536 |
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