SML1910
IC87201
≥98% (HPLC)
别名:
2-[(1H-Benzotriazol-6-ylamino)methyl]-4,6-dichloro-phenol, 2-[(1H-Benzotriazol-6-ylamino)methyl]-4,6-dichlorophenol, IC 87201, IC-87201, Phenol, 2-[(1H-benzotriazol-6-ylamino)methyl]-4,6-dichloro-
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to brown
溶解性
DMSO: 5 mg/mL, clear
储存温度
2-8°C
SMILES字符串
Clc1c(c(cc(c1)Cl)CNc2cc3[nH]nnc3cc2)O
InChI
1S/C13H10Cl2N4O/c14-8-3-7(13(20)10(15)4-8)6-16-9-1-2-11-12(5-9)18-19-17-11/h1-5,16,20H,6H2,(H,17,18,19)
InChI key
QEHVTUCLCBXQIC-UHFFFAOYSA-N
生化/生理作用
IC87201 is a potent inhibitor of the nNOS/PSD-95 protein-protein interaction that blocks NMDA-induced 3′ ,5′ -cyclic guanosine monophosphate (cGMP) production in hippocampal cultures.
IC87201 is a potent inhibitor of the nNOS/PSD-95 protein-protein interaction that blocks NMDA-induced 3′ ,5′ -cyclic guanosine monophosphate (cGMP) production in hippocampal cultures. IC87201 exhibits analgesic properties in mice pain models. Contrary to NMDA receptor antagonists nNOS/PSD-95 protein-protein interaction inhibitors spared source memory, spatial memory, and motor function in rats.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
法规信息
新产品
此项目有
S K Florio et al.
British journal of pharmacology, 158(2), 494-506 (2009-09-08)
Post-synaptic density protein 95 (PSD95) contains three PSD95/Dosophilia disc large/ZO-1 homology domains and links neuronal nitric oxide synthase (nNOS) with the N-methyl-D-aspartic acid (NMDA) receptor. This report assesses the effects of disruption of the protein-protein interaction between nNOS and PSD95
Alexandra E Smith et al.
Behavioural brain research, 305, 23-29 (2016-02-26)
Limitations of preclinical models of human memory contribute to the pervasive view that rodent models do not adequately predict therapeutic efficacy in producing cognitive impairments or improvements in humans. We used a source-memory model (i.e., a representation of the origin
Anders Bach et al.
Scientific reports, 5, 12157-12157 (2015-07-17)
ZL006 and IC87201 have been presented as efficient inhibitors of the nNOS/PSD-95 protein-protein interaction and shown great promise in cellular experiments and animal models of ischemic stroke and pain. Here, we investigate the proposed mechanism of action of ZL006 and
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持