SML1954
X-34
≥90% (HPLC), powder, amyloid-specific fluorescent dye
别名:
1,4-双(3-羧基-4-羟基苯基乙烯基)苯
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关于此项目
经验公式（希尔记法）:
C24H18O6
化学文摘社编号:
分子量:
402.40
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
X-34, ≥90% (HPLC)
InChI
1S/C24H18O6/c25-21-11-9-17(13-19(21)23(27)28)7-5-15-1-2-16(4-3-15)6-8-18-10-12-22(26)20(14-18)24(29)30/h1-14,25-26H,(H,27,28)(H,29,30)
InChI key
MCBNOAYTZBUCSX-UHFFFAOYSA-N
SMILES string
OC(C=C1)=C(C(O)=O)C=C1C=CC2=CC=C(C=CC3=CC=C(O)C(C(O)=O)=C3)C=C2
assay
≥90% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2.0 mg/mL, clear
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
X-34是一种荧光淀粉样特异性染料。 它与Pittsburgh CompoundB的结合位点不同，并且是β-折叠结构的一种高度荧光标记。
X-34（1,4-双（3-羧基-4-羟基苯基乙烯基）-苯）是参与到降低Aβ42水平（淀粉样-β肽的42个残基异构体）的一种小分子γ-分泌酶调节因子（GSM）。X-34还被用于在活的转基因秀丽隐杆线虫体内对具有经典淀粉样纤维超微结构的细胞内免疫反应性沉积物进行可视化。它还可作为组织化学染色剂用于确定阿尔茨海默氏′病（AD）的病理变化。
荧光淀粉样特异性染料
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Chantal M Ferguson et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association, 20(4), 2632-2652 (2024-02-20)
The most significant genetic risk factor for late-onset Alzheimer's disease (AD) is APOE4, with evidence for gain- and loss-of-function mechanisms. A clinical need remains for therapeutically relevant tools that potently modulate APOE expression. We optimized small interfering RNAs (di-siRNA, GalNAc)
Andy P Tsai et al.
Neurobiology of disease, 153, 105303-105303 (2021-02-26)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, robust microgliosis, neuroinflammation, and neuronal loss. Genome-wide association studies recently highlighted a prominent role for microglia in late-onset AD (LOAD). Specifically, inositol polyphosphate-5-phosphatase (INPP5D), also known as SHIP1
Substrate-targeting ?-secretase modulators
Kukar TL
Nature, 453, 925-929 (2008)
Marcus Bäck et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 22(51), 18335-18338 (2016-11-04)
Deposits comprised of amyloid-β (Aβ) are one of the pathological hallmarks of Alzheimer's disease (AD) and small hydrophobic ligands targeting these aggregated species are used clinically for the diagnosis of AD. Herein, we observed that anionic oligothiophenes efficiently displaced X-34
Sangderk Lee et al.
Cell reports, 42(3), 112196-112196 (2023-03-06)
The E4 allele of Apolipoprotein E (APOE) is associated with both metabolic dysfunction and a heightened pro-inflammatory response: two findings that may be intrinsically linked through the concept of immunometabolism. Here, we combined bulk, single-cell, and spatial transcriptomics with cell-specific
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