SML1954
X-34
≥90% (HPLC), powder, amyloid-specific fluorescent dye
别名:
1,4-双(3-羧基-4-羟基苯基乙烯基)苯
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关于此项目
经验公式（希尔记法）:
C24H18O6
化学文摘社编号:
分子量:
402.40
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
X-34, ≥90% (HPLC)
InChI
1S/C24H18O6/c25-21-11-9-17(13-19(21)23(27)28)7-5-15-1-2-16(4-3-15)6-8-18-10-12-22(26)20(14-18)24(29)30/h1-14,25-26H,(H,27,28)(H,29,30)
InChI key
MCBNOAYTZBUCSX-UHFFFAOYSA-N
SMILES string
OC(C=C1)=C(C(O)=O)C=C1C=CC2=CC=C(C=CC3=CC=C(O)C(C(O)=O)=C3)C=C2
assay
≥90% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2.0 mg/mL, clear
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
X-34是一种荧光淀粉样特异性染料。 它与Pittsburgh CompoundB的结合位点不同，并且是β-折叠结构的一种高度荧光标记。
X-34（1,4-双（3-羧基-4-羟基苯基乙烯基）-苯）是参与到降低Aβ42水平（淀粉样-β肽的42个残基异构体）的一种小分子γ-分泌酶调节因子（GSM）。X-34还被用于在活的转基因秀丽隐杆线虫体内对具有经典淀粉样纤维超微结构的细胞内免疫反应性沉积物进行可视化。它还可作为组织化学染色剂用于确定阿尔茨海默氏′病（AD）的病理变化。
荧光淀粉样特异性染料
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34
Link CD
Neurobiology of Aging, 22, 217-226 (2001)
Taweesak Tangrodchanapong et al.
Molecules (Basel, Switzerland), 26(8) (2021-05-01)
The pathological finding of amyloid-β (Aβ) aggregates is thought to be a leading cause of untreated Alzheimer's disease (AD). In this study, we isolated 2-butoxytetrahydrofuran (2-BTHF), a small cyclic ether, from Holothuria scabra and demonstrated its therapeutic potential against AD
S D Styren et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 48(9), 1223-1232 (2000-08-19)
X-34, a lipophilic, highly fluorescent derivative of Congo red, was examined as a histochemical stain for pathological changes in Alzheimer's disease (AD). X-34 intensely stained neuritic and diffuse plaques, neurofibrillary tangles (NFTs), neuropil threads, and cerebrovascular amyloid. Comparison to standard
Chantal M Ferguson et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association, 20(4), 2632-2652 (2024-02-20)
The most significant genetic risk factor for late-onset Alzheimer's disease (AD) is APOE4, with evidence for gain- and loss-of-function mechanisms. A clinical need remains for therapeutically relevant tools that potently modulate APOE expression. We optimized small interfering RNAs (di-siRNA, GalNAc)
Substrate-targeting ?-secretase modulators
Kukar TL
Nature, 453, 925-929 (2008)
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