SML2000
3-BrOP
≥98% (GC)
别名:
3-BrPA 丙酯, 3-溴-2-氧代丙酸-1-丙酯, 3-溴-2-氧代丙酸丙酯, 3-溴丙酮丙酯, 甘氨酸
assay
≥98% (GC)
form
oil
color
colorless to yellow
shipped in
ambient
storage temp.
2-8°C
Biochem/physiol Actions
3-BrOP 是糖酵解抑制剂 3-溴丙酮酸 (3-BrPA) 的一种细胞渗透性酯，已知可靶向己糖激酶 II (HK2) 和 GAPDH。3-BrOP 进入细胞后被细胞内酯酶水解为 3-BrPA。3-BrOP 与 mTOR 抑制剂雷帕霉素具有协同杀伤肿瘤细胞的作用（雷帕霉素 100 ng/mL/mL 诱导肿瘤细胞凋亡 = 64%/36%Raji 人淋巴瘤细胞 + 40 μmol/l 雷帕霉素 40 μmol/l）。M 3-BrOP 和 72%/45% 的 HL-60 白血病细胞经 20μM 3-BrOP in 24 h）由于细胞 ATP 耗竭和葡萄糖摄取抑制增强。通过尾静脉注射给药，3-BrOP 可显著抑制 SK-N-SH 异种移植物来源的神经母细胞瘤在小鼠体内的肿瘤生长（14 天内增长 78%；20 mg/kg/天）。
糖酵解抑制剂 3-溴丙酮酸 (3-BrPA) 的细胞渗透性酯，具有体外和体内抗癌疗效。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Alejandro G Levy et al.
Investigational new drugs, 30(1), 191-199 (2010-10-05)
Children with high-risk and recurrent neuroblastoma have poor survival rates, and novel therapies are needed. Many cancer cells have been found to preferentially employ the glycolytic pathway for energy generation, even in the presence of oxygen. 3-BrOP is a novel
H-Q Ju et al.
Leukemia, 31(10), 2143-2150 (2017-02-15)
Internal tandem duplication (ITD) mutation in Fms-like tyrosine kinase 3 gene (FLT3/ITD) represents an unfavorable genetic change in acute myeloid leukemia (AML) and is associated with poor prognosis. Metabolic alterations have been involved in tumor progression and attracted interest as
R-H Xu et al.
Leukemia, 19(12), 2153-2158 (2005-09-30)
The mammalian target of rapamycin (mTOR) pathway plays important roles in regulating nutrient metabolism and promoting the growth and survival of cancer cells, which exhibit increased glycolysis for ATP generation. In this study, we tested the hypothesis that inhibition of
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