方案
≥98% (GC)
表单
oil
颜色
colorless to yellow
运输
ambient
储存温度
2-8°C
生化/生理作用
3-BrOP 是糖酵解抑制剂 3-溴丙酮酸 (3-BrPA) 的一种细胞渗透性酯，已知可靶向己糖激酶 II (HK2) 和 GAPDH。3-BrOP 进入细胞后被细胞内酯酶水解为 3-BrPA。3-BrOP 与 mTOR 抑制剂雷帕霉素具有协同杀伤肿瘤细胞的作用（雷帕霉素 100 ng/mL/mL 诱导肿瘤细胞凋亡 = 64%/36%Raji 人淋巴瘤细胞 + 40 μmol/l 雷帕霉素 40 μmol/l）。M 3-BrOP 和 72%/45% 的 HL-60 白血病细胞经 20μM 3-BrOP in 24 h）由于细胞 ATP 耗竭和葡萄糖摄取抑制增强。通过尾静脉注射给药，3-BrOP 可显著抑制 SK-N-SH 异种移植物来源的神经母细胞瘤在小鼠体内的肿瘤生长（14 天内增长 78%；20 mg/kg/天）。
糖酵解抑制剂 3-溴丙酮酸 (3-BrPA) 的细胞渗透性酯，具有体外和体内抗癌疗效。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
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Children with high-risk and recurrent neuroblastoma have poor survival rates, and novel therapies are needed. Many cancer cells have been found to preferentially employ the glycolytic pathway for energy generation, even in the presence of oxygen. 3-BrOP is a novel
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