SML2501
MF-094
≥98% (HPLC)
别名:
(S)-N-(1-((5-(N-(tert-butyl)sulfamoyl)naphthalen-1-yl)amino)-1-oxo-3-phenylpropan-2-yl)cyclohexanecarboxamide
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
[S](=O)(=O)(NC(C)(C)C)c1c2c(c(ccc2)NC(=O)[C@@H](NC(=O)C4CCCCC4)Cc3ccccc3)ccc1
InChI key
DQXORJHBZHLLTE-SANMLTNESA-N
相关类别
生化/生理作用
Inhibitor of ubiquitin specific protease 30 (USP30)
MF-094 is a potent inhibitor of ubiquitin specific protease 30 (USP30), a de-ubiquitinating enzymes (DUB) that opposes the action of parkin-mediated ubiquitination in clearing damaged mitochondria. MF-094 is selective for USP30 with an IC50 value of 120 nM, compared to >10 μM for USPs 1, 8, and 9.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
Hang Zhu et al.
Redox biology, 38, 101777-101777 (2020-11-10)
The death of cardiomyocytes either through apoptosis or necroptosis is the pathological feature of cardiac ischemia-reperfusion (I/R) injury. Phosphoglycerate mutase 5 (PGAM5), a mitochondrially-localized serine/threonine-protein phosphatase, functions as a novel inducer of necroptosis. However, intense debate exists regarding the effect
Arthur F Kluge et al.
Bioorganic & medicinal chemistry letters, 28(15), 2655-2659 (2018-06-25)
Mitophagy is one of the processes that cells use to maintain overall health. An E3 ligase, parkin, ubiquitinates mitochondrial proteins prior to their degradation by autophagasomes. USP30 is an enzyme that de-ubiquitinates mitochondrial proteins; therefore, inhibiting this enzyme could foster
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