SML2675
CuET
≥97% (HPLC)
别名:
Copper bis(N,N-diethyldithiocarbamate), Cupric diethyldithiocarbamate, Merkupral, NSC 177697, bis(N,N-Diethyldithiocarbamato)copper(II)
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关于此项目
经验公式（希尔记法）:
C10H20CuN2S4
化学文摘社编号:
分子量:
360.09
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
CuET, ≥97% (HPLC)
InChI
1S/2C5H11NS2.Cu/c2*1-3-6(4-2)5(7)8;/h2*3-4H2,1-2H3,(H,7,8);/q;;+2/p-2
SMILES string
CCN(CC)C(S[Cu]SC(N(CC)CC)=S)=S
InChI key
OBBCYCYCTJQCCK-UHFFFAOYSA-L
assay
≥97% (HPLC)
form
powder
storage condition
desiccated
color
dark green to black
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
CuET, a metabolite of disulfiram, is an inhibitor of p97 segregase adaptor NPL4 that exhibits potent anti-cancer effects. Apparently CuET binds NPL4 and induces its aggregation, which disables the vital p97–NPL4–UFD1 pathway and induces to cell death.
Inhibitor of NPL4
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Tomoya Fujie et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 21(2), 263-273 (2016-01-31)
The interest in organic-inorganic hybrid molecules as molecular probes for biological systems has been growing rapidly. Such hybrid molecules exhibit unique biological activities. Herein, copper(II) bis(diethyldithiocarbamate) (Cu10) was found to activate the transcription factor NF-E2-related factor 2 (Nrf2), which is
Zdenek Skrott et al.
Nature, 552(7684), 194-199 (2017-12-07)
Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A promising approach to meet the need for improved cancer treatment is drug repurposing. Here we highlight the potential for repurposing disulfiram (also
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