SML2741
Sultopride hydrochloride
≥98% (HPLC)
别名:
(±)-Sultopride HCl, LIN 1418 HCl, LIN1418 HCl, N-[(1-Ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide hydrochloride, N-[(1-Ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-o-anisamide monohydrochloride
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
[S](=O)(=O)(CC)c1cc(c(cc1)OC)C(=O)NCC2[N+H](CCC2)CC.[Cl-]
InChI
1S/C17H26N2O4S.ClH/c1-4-19-10-6-7-13(19)12-18-17(20)15-11-14(24(21,22)5-2)8-9-16(15)23-3;/h8-9,11,13H,4-7,10,12H2,1-3H3,(H,18,20);1H
InChI key
IGOWMQPOGQYFFM-UHFFFAOYSA-N
生化/生理作用
Orally active benzamide class dopamine receptor D2/3-selective antagonist (Ki = 18 nM/D2, 22 nM/D3, 7.7 μM/D4, >10 μM/D1) with in vivo antipsychotic efficacy.
Sultopride is an orally active benzamide class dopamine receptor D2/3-selective antagonist (Ki = 18 nM/rat D2, 22 nM/human D3, 7.7 μM/human D4, >10 μM/rat D1 by competitive binding against 0.5 nM Spiperone, 0.2 nM YM-09151-2, 5 nM Spiperone, 0.2 nM SCH23390 for respective receptor) that displays in vivo antipsychotic efficacy with moderate atypical index. Sultopride exhibits little or no affinity toward 5-HT1A2/33, adrenaline receptor α1/α2, Ach receptor, histamine receptor H1, or Sigma receptors σ1/σ2. Sultopride is a racemic material composed of the highly active (-) and the less potent (+) enenatiomers.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
Takuro Oka et al.
Life sciences, 76(2), 225-237 (2004-11-03)
Acute administration of typical and atypical antipsychotics has been reported to induce regionally distinct patterns of c-Fos expression in the rat forebrain. Furthermore, atypical index, the difference in the extent of increased Fos-like immunoreactivity (Fos-LI) in the nucleus accumbens (NAc)
Akihiro Takano et al.
The international journal of neuropsychopharmacology, 9(5), 539-545 (2005-11-18)
Conventional antipsychotics tend to elicit extrapyramidal symptoms at clinical doses, but dose optimization could reduce the risk of such side-effects. In-vivo receptor-binding studies have suggested that 70-80% of dopamine D2 receptor occupancy provides the desired antipsychotic effects without extrapyramidal symptoms.
Jun-ichi Karasawa et al.
Pharmacology, biochemistry, and behavior, 73(3), 505-510 (2002-08-02)
(R)-(+)-1-(4-Chlorophenyl)-3-[4-(2-methoxyethyl)piperazin-1-yl]methyl-2-pyrrolidinone L-tartrate (MS-377) is a novel antipsychotic agent with selective and high affinity for sigma(1) receptor. The present study was carried out to clarify the interaction of MS-377 with dopamine D(2) receptor antagonists (D(2) antagonists) in concurrent administration, and then
S Takahashi et al.
Naunyn-Schmiedeberg's archives of pharmacology, 364(1), 81-86 (2001-08-04)
Phencyclidine (PCP)-induced head-weaving is inhibited by a novel selective sigma1-ligand, (R)-(+)-1-(4-chlorophenyl)-3-[4-(2-methoxyethyl)piperazin-1-yl]methyl-2-pyrrolidinone L-tartrate (MS-377), but not by dopamine D2 antagonists. In the present study, we examined the effects of two potent and selective sigma1-ligands, MS-377 and N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl) ethylamine (NE-100), on PCP-induced
M Ozaki et al.
Neuropharmacology, 34(5), 473-480 (1995-05-01)
The effects of the dopamine antagonists haloperidol and sultopride were investigated on the twitch response, evoked by 0.1 Hz stimulation of guinea-pig isolated ileal longitudinal muscle, and on the inhibition of the twitch response induced by 10 Hz stimulation (post-tetanic
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