SML2768
Vicriviroc Maleate
≥98% (HPLC)
别名:
(4,6-Dimethyl-5-pyrimidinyl)[4-[(3S)-4-[(1R)-2-methoxy-1-[4-(trifluoromethyl)phenyl]ethyl]-3-methyl-1-piperazinyl]-4-methyl-1-piperidinyl]methanone Maleate, MK 7690, SCH 417690, SCH-D
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关于此项目
经验公式（希尔记法）:
C28H38F3N5O2·C4H4O4
化学文摘社编号:
分子量:
649.70
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
O=C(/C=C\C(O)=O)O.FC(F)(F)C(C=C1)=CC=C1[C@H](COC)N([C@@H](C)C2)CCN2C(CC3)(C)CCN3C(C4=C(C)N=CN=C4C)=O
InChI
1S/C28H38F3N5O2.C4H4O4/c1-19-16-35(14-15-36(19)24(17-38-5)22-6-8-23(9-7-22)28(29,30)31)27(4)10-12-34(13-11-27)26(37)25-20(2)32-18-33-21(25)3;5-3(6)1-2-4(7)8/h6-9,18-19,24H,10-17H2,1-5H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t19-,24-;/m0./s1
InChI key
GXINKQQWHLIBJA-UCIBKFKQSA-N
相关类别
生化/生理作用
Inhibitor of chemokine CCR5 receptors; Antiretroviral entry inhibitor
Vicriviroc is an orally available, potent and selective allosteric antagonist of C-C chemokine CCR5 receptors. Vicriviroc inhibits the interaction of HIV-1 with CCR5 receptor thereby preventing HIV-1 virus entry into cells.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
法规信息
新产品
此项目有
Reem Berro et al.
Journal of virology, 87(12), 6569-6581 (2013-03-08)
Small-molecule CCR5 inhibitors such as vicriviroc (VVC) and maraviroc (MVC) are allosteric modulators that impair HIV-1 entry by stabilizing a CCR5 conformation that the virus recognizes inefficiently. Viruses resistant to these compounds are able to bind the inhibitor-CCR5 complex while
Paul McNicholas et al.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 55(2), 134-139 (2012-07-25)
Vicriviroc (VCV), a small-molecule antagonist of the C-C chemokine receptor 5 (CCR5), blocks HIV's entry into CD4+ cells. Small studies have suggested that resistance to CCR5 antagonists is slow to develop. To examine resistance to VCV in isolates from treatment
Xuanmao Jiao et al.
Cancer research, 78(7), 1657-1671 (2018-01-24)
The functional significance of the chemokine receptor CCR5 in human breast cancer epithelial cells is poorly understood. Here, we report that CCR5 expression in human breast cancer correlates with poor outcome. CCR5+ breast cancer epithelial cells formed mammospheres and initiated
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