SML2790
YU254403
≥98% (HPLC)
别名:
4-{7,9-dichloro-1H,2H,3H,3aH,4H,5H,9bH-cyclopenta[c]quinolin-4-yl}benzoic acid
产品名称
YU254403, ≥98% (HPLC)
InChI
1S/C19H17Cl2NO2/c20-12-8-15(21)17-13-2-1-3-14(13)18(22-16(17)9-12)10-4-6-11(7-5-10)19(23)24/h4-9,13-14,18,22H,1-3H2,(H,23,24)
InChI key
PHDZTYHPMHMZPG-UHFFFAOYSA-N
SMILES string
O=C(C1=CC=C(C(NC2=CC(Cl)=C3)C4CCCC4C2=C3Cl)C=C1)O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
YU254403 is a potent inhibitor of phosphatidylserine decarboxylases (PSD) including Plasmodium knowlesi phosphatidylserine decarboxylases (PkPSD). YU254403 potently inhibits growth of pathogenic yeast Candida albicans, and other pathogens including Aspergillus fumigatus and Fusarium solani.
potent inhibitor of phosphatidylserine decarboxylases (PSD)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Adam Hendricson et al.
The Journal of biological chemistry, 294(32), 12146-12156 (2019-06-23)
Phosphatidylserine decarboxylases (PSDs) catalyze the decarboxylation of phosphatidylserine to generate phosphatidylethanolamine, a critical step in phospholipid metabolism in both prokaryotes and eukaryotes. Most PSDs are membrane-bound, and classical radioisotope-based assays for determining their activity in vitro are not suitable for
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