SML2831
VU041
≥98% (HPLC)
别名:
1,2,3,4-Tetrahydro-1-[[4,5,6,7-tetrahydro-3-(trifluoromethyl)-1H-indazol-1-yl]acetyl]-quinoline, 1-(3,4-Dihydroquinolin-1(2H)-yl)-2-(3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)ethan-1-one, VU0048041
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C(CN1N=C(C2=C1CCCC2)C(F)(F)F)N3CCCC4=C3C=CC=C4
InChI
1S/C19H20F3N3O/c20-19(21,22)18-14-8-2-4-10-16(14)25(23-18)12-17(26)24-11-5-7-13-6-1-3-9-15(13)24/h1,3,6,9H,2,4-5,7-8,10-12H2
InChI key
DLAGRCZUELSZFG-UHFFFAOYSA-N
生化/生理作用
VU041 is a mosquito cuticle penetrant, potent and selective inhibitor of inwardly rectifying potassium (Kir) channel of Aedes aegypti (AeKir1) and Anopheles gambiae (AnKir1) that exhibits potent toxicity to adult insecticide-susceptible and -resistant strains of female mosquitoes. VU041 is selective for mosquito Kir channels over several mammalian orthologs. Also, VU041 is toxic to mosquito larvae when present in water.
mosquito cuticle penetrant, potent and selective inhibitor of Kir channel of Aedes aegypti and Anopheles gambiae; selective for mosquito Kir channels over several mammalian orthologs
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Renata Rusconi Trigueros et al.
Insects, 9(4) (2018-11-18)
The inward rectifier potassium (Kir) channels play key roles in the physiology of mosquitoes and other insects. Our group, among others, previously demonstrated that small molecule inhibitors of Kir channels are promising lead molecules for developing new insecticides to control
Daniel R Swale et al.
Scientific reports, 6, 36954-36954 (2016-11-17)
Insecticide resistance is a growing threat to mosquito control programs around the world, thus creating the need to discover novel target sites and target-specific compounds for insecticide development. Emerging evidence suggests that mosquito inward rectifier potassium (Kir) channels represent viable
Zhilin Li et al.
Pest management science, 75(10), 2725-2734 (2019-02-21)
The unique feeding biology of aphids suggests novel insecticide targets are likely to exist outside of the nervous system. We therefore aimed to directly test the hypothesis that pharmacological inhibition of inward rectifier potassium (Kir) channels would result in salivary
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