SML2908
A71915 trifluoroacetate
≥95% (HPLC)
别名:
(Arg6, β-cyclohexyl-Ala8, D-Tic16, Arg17, Cys18)-Atrial Natriuretic Factor (6-18) amide (Cys7→Cys18 disulfide), TFA salt, A 71915, A-71915, Arg-Cys-β-cyclohexyl-Ala-Gly-Gly-Arg-Ile-Asp-Arg-Ile-D-Tic-Arg-Cys-NH2 (Cys2→Cys13 disulfide), TFA salt, RC-(Cha)-GGRIDRI-(D-Tic)-RC-NH2 (Cys2→Cys13 disulfide, TFA salt, [Arg6, Cha8]ANP-(6-15)-D-Tic-Arg-Cys-NH2 (Cys7→Cys18 disulfide), TFA salt
生化/生理作用
A71915 is a potent atrial natriuretic peptide A (ANP, NPPA) receptor (NPR1, ANP-A, ANPR-A, NPR-A) antagonist (pKi = 9.18 (Ki = 650 nM) by competitive binding against 300 nM rat ANP1-28 to human neuroblastoma NB-OK-1 cells; pA2 = 9.45 against rat ANP-induced cGMP production in NB-OK-1 cells). A71915 is reactive toward dog, human, mouse, rabbit, and rat species, and commonly employed both in cultures (1-10 μM) and in vivo for studying NPR-A-mediated responses.
Atrial natriuretic peptide A (ANP, NPPA) receptor (NPR1, ANPRA, NPRA) antagonist with in vitro and in vivo efficacy.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
历史批次信息供参考:
Shuyuan Chu et al.
Peptides, 90, 1-9 (2017-02-24)
Atrial natriuretic peptide (ANP) is increasingly expressed on airway and inhibits pulmonary arterial remodeling. However, the role of ANP in remodeling of respiratory system is still unclear. The role of ANP on airway remodeling and the possible mechanism was explored
André M Leite-Moreira et al.
Cardiovascular research, 114(5), 656-667 (2018-02-06)
The heart is constantly challenged with acute bouts of stretching or overload. Systolic adaptations to these challenges are known but adaptations in diastolic stiffness remain unknown. We evaluated adaptations in myocardial stiffness due to acute stretching and characterized the underlying
G J Trachte
The Journal of pharmacology and experimental therapeutics, 264(3), 1227-1233 (1993-03-01)
Atrial natriuretic factor (ANF) suppresses adrenergic and purinergic neurotransmission in the rabbit vas deferens. The neuromodulatory mechanism of action for ANF is not established, but is thought to be independent of cyclic GMP (cGMP) generation. This study directly tested for
C Delporte et al.
European journal of pharmacology, 224(2-3), 183-188 (1992-12-02)
The effects of seven competitive atrial natriuretic peptide (ANP) receptor antagonists were compared on cultured human neuroblastoma NB-OK-1 cells expressing exclusively ANPA receptors, by evaluating their capacity to inhibit [125I]ANP binding and to suppress ANP-stimulated cyclic GMP elevation. In ANP
L L Norling et al.
Biology of the neonate, 66(5), 294-301 (1994-01-01)
Atrial natriuretic peptide (ANP) regulates glomerular hemodynamics by interaction with biologic receptors (GC-A/ANP) that possess particulate guanylyl cyclase activity. In a previous study we have shown a developmental difference in glomerular response to ANP where preweaned glomeruli produced significantly less
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持