SML2947
Penehyclidine hydrochloride
≥98% (HPLC)
别名:
α-[(1-Azabicyclo[2.2.2]oct-3-yloxy)methyl]-α-cyclopentyl-benzenemethanol hydrochloride, 3-(2′-phenyl-2′-cyclopentyl-2′-hydroxyl-ethoxy) quinuclidine, Penequine hydrochloride, Penequinine
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关于此项目
经验公式（希尔记法）:
C20H29NO2 · HCl
化学文摘社编号:
分子量:
351.91
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
[Cl-].N21CC(C(CC2)CC1)OCC(O)(C4CCCC4)c3ccccc3.[H+]
InChI
1S/C20H29NO2.ClH/c22-20(18-8-4-5-9-18,17-6-2-1-3-7-17)15-23-19-14-21-12-10-16(19)11-13-21;/h1-3,6-7,16,18-19,22H,4-5,8-15H2;1H
InChI key
DDTVVMRZNVIVQM-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder (hygroscopic)
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Penehyclidine hydrochloride is a brain penetrant anticholinergic drug that exhibits both antimuscarinic and antinicotinic activity. Penehyclidine hydrochloride does not induce muscarinic 2 receptor-associated cardiovascular side effects. Penehyclidine hydrochloride is effective in experimental models of heart, lung and brain ischemia reperfusion injury.
brain penetrant anticholinergic drug that exhibits both antimuscarinic and antinicotinic activity
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Yong-An Wang et al.
Life sciences, 78(2), 210-223 (2005-09-13)
Previous studies have paid little attention to the anticonvulsant effect of anticholinergic drugs that act on both muscarinic (M) and nicotinic (N) receptors during soman-induced seizures. Therefore, with the establishment of a soman-induced seizures model in rats, this study evaluated
Yaguang Wang et al.
European journal of pharmacology, 839, 1-11 (2018-09-12)
Penehyclidine hydrochloride (PHC) is a new anticholinergic agent that provides protective effects in experimental models of heart and brain ischaemia as well as reperfusion (I/R) injury. In this study, we tested the hypothesis that PHC can alleviate lung ischaemia-reperfusion injury
Yaguang Wang et al.
Drug design, development and therapy, 12, 3289-3299 (2018-10-17)
Penehyclidine hydrochloride (PHC) is an anticholinergic drug manufactured in China. It is used widely in clinics as a reversal agent in cases of organic phosphorus poisoning and as a preanesthetic medication. Compared with other anticholinergic agents, PHC confers substantial advantages.
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