SML2988
Tat-NR2B9c trifluoroacetate
≥95% (HPLC)
别名:
NA-1, trifluoroacetate salt, Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Leu-Ser-Ser-Ile-Glu-Ser-Asp-Val, trifluoroacetate salt, YGRKKRRQRRR-KLSSIESDV, trifluoroacetate salt
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关于此项目
经验公式（希尔记法）:
C105H188N42O30 · xC2HF3O2
化学文摘社编号:
分子量:
2518.88 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
Biochem/physiol Actions
NMDAR-PSD-95 interaction blocking peptide with neuroprotective efficacy in vitro and in vivo.
Tat-NR2B9c (NA-1) is a 20-mer peptide composed of a membrane-permeant HIV-1 Tat protein transduction domain sequence (a.a. 47-57) N-terminal to the NMDA receptor (NMDAR) GluN2B carboxyl tail sequence KLSSIESDV that blocks intracellular NMDAR-PSD-95 interaction-induced neurotoxic signaling without affecting NMDAR-mediated synaptic activity or calcium influx. NA-1 protects cultured cortical neurons from NMDA excitotoxicity (50 nM; 20/40/100 μM NMDA) and reduces focal ischemic brain damage in rats in vivo (3 μmol/kg iv. bolus 1 hr post MCAO onset).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Karen Tse et al.
Journal of neuroscience research, 97(11), 1378-1392 (2019-05-16)
Antiepileptogenic agents that prevent the development of epilepsy following a brain insult remain the holy grail of epilepsy therapeutics. We have employed a label-free proteomic approach that allows quantification of large numbers of brain-expressed proteins in a single analysis in
Gabriella MacDougall et al.
Journal of molecular neuroscience : MN, 61(2), 235-246 (2016-11-21)
We have previously reported that cationic poly-arginine and arginine-rich cell-penetrating peptides display high-level neuroprotection and reduce calcium influx following in vitro excitotoxicity, as well as reduce brain injury in animal stroke models. Using the neuroprotective peptides poly-arginine R12 (R12) and
Diego Milani et al.
Brain research bulletin, 135, 62-68 (2017-10-02)
Following positive results with the poly-arginine peptide R18 when administered intravenously 30 or 60min after permanent and/or transient middle cerebral artery occlusion (MCAO; 90min) in the rat, we examined the effectiveness of the peptide when administered 2h after MCAO. R18
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML2988-1MG | 04065265445856 |
| SML2988-5MG | 04065265445863 |