SML3265
DAPTA trifluoroacetate
≥95% (HPLC)
别名:
Adaptavir trifluoroacetate, D-Ala-Peptide T-NH2 trifluoroacetate, D-Ala-Peptide T-amide trifluoroacetate, Dala1-Peptide T-NH2 trifluoroacetate, Dala1-Peptide T-amide trifluoroacetate, H-D-Ala-STTTNYT-NH2 trifluoroacetate, H-D-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-NH2 trifluoroacetate, [D-Ala1]-Peptide T-NH2 trifluoroacetate, [D-Ala1]-Peptide T-amide trifluoroacetate
生化/生理作用
DAPTA is a potent CCR5 antagonist, an amidated octapeptide corresponding to an HIV envelope glycoprotein gp120 (gp160)-derived sequence (aa 185-192; the SF-2 isolate) that competes against gp120-CD4 complex for interaction with CCR5 (IC50 = 0.42 nM against gp120CM235 binding to CCR5/CD4 cells, IC50 = 1.5/1.8 nM against gp120BaL/sCD4 or gp120CM235/sCD4 binding to CCR5+/CD4- cells). DAPTA blocks CCR5-dependent HIV host cell entry in cultures and in vivo.
Potent CCR5 antagonist that blocks CCR5-dependent HIV host cell entry in cultures and in vivo.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
Valeria Avdoshina et al.
AIDS (London, England), 34(7), 979-988 (2020-02-20)
Postmortem brains of patients diagnosed with HIV-1-associated neurocognitive disorders (HAND) exhibit loss of dendrites. However, the mechanisms by which synapses are damaged are not fully understood. Dendrite length and remodeling occurs via microtubules, the dynamics of which are regulated by
Weiwei Yu et al.
Frontiers in pharmacology, 12, 551839-551839 (2021-05-07)
Background: Cigarette smoke exposure (CSE) is a major cause of chronic obstructive pulmonary disease (COPD). The smoke disrupts cell-cell adhesion by inducing epithelial barrier damage to the tight junction (TJ) proteins. Even though the inflammatory mechanism of chemokine (C-C motif)
Sheikh F Ahmad et al.
European journal of pharmacology, 846, 100-108 (2019-01-19)
Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder characterized by deficits in social interaction, communication, and repetitive behaviors. BTBR T+ Itpr3tf/J (BTBR) mice, a preclinical autistic model featuring ASD symptoms as defined by social relations, was used in this
C Liapi et al.
The Journal of investigative dermatology, 110(4), 332-337 (1998-04-16)
In addition to acquired immunodeficiency syndrome (AIDS), persons infected with human immunodeficiency virus often develop cutaneous manifestations, including severe psoriasis. In previous studies, we have established that psoriatic fibroblasts and erythrocytes obtained from psoriatic patients exhibit decreased levels of cyclic
Maria T Polianova et al.
Antiviral research, 67(2), 83-92 (2005-07-09)
The chemokine receptor CCR5 plays a crucial role in transmission of HIV isolates, which predominate in the early and middle stages of infection, as well as those, which populate the brain and cause neuro-AIDS. CCR5 is therefore an attractive therapeutic
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