SML3292
8-nitro-Cgmp Sodium
≥98% (HPLC)
别名:
8-Nitro-guanosine cyclic 3′,5′-(hydrogen phosphate) sodium, 8-Nitro-guanosine 3′,5′-cyclic monophosphate sodium
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
储存温度
−20°C
SMILES字符串
O[C@@H]1[C@@H]([C@@H](CO2)O[C@H]1N3C([N+]([O-])=O)=NC4=C3N=C(NC4=O)N)OP2([O-])=O.[Na+]
生化/生理作用
8-nitro-cGMP is a second messenger of nitric oxide, which is involved in intracellular redox signaling. 8-nitro-cGMP is a potent inhibitor of tau aggregation. 8-nitro-cGMP induces S-guanylation of tau both in vitro and in tau overexpressed HEK293T cells, which inhibits heparin-induced tau aggregation.
potent inhibitor of tau aggregation; second messenger of nitric oxide
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Motohiro Nishida et al.
Journal of clinical biochemistry and nutrition, 58(2), 91-98 (2016-03-26)
Redox signaling is a key modulator of oxidative stress induced by nonspecific insults of biological molecules generated by reactive oxygen species. Current redox biology is revisiting the traditional concept of oxidative stress, such that toxic effects of reactive oxygen species
Jun Yoshitake et al.
The Journal of biological chemistry, 291(43), 22714-22720 (2016-09-08)
Neurofibrillar tangles caused by intracellular hyperphosphorylated tau inclusion and extracellular amyloid β peptide deposition are hallmarks of Alzheimer's disease. Tau contains one or two cysteine residues in three or four repeats of the microtubule binding region following alternative splicing of
Marek Petřivalský et al.
Frontiers in plant science, 11, 598-598 (2020-06-09)
Nitration of diverse biomolecules, including proteins, lipids and nucleic acid, by reactive nitrogen species represents one of the key mechanisms mediating nitric oxide (NO) biological activity across all types of organisms. 8-nitroguanosine 3'5'-cyclic monophosphate (8-nitro-cGMP) has been described as a
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