SML3343
TC14012 Trifluoroacetate
≥95% (HPLC)
别名:
([Cit(6), D-Cit(8)]-T140 with C-terminal amide, TFA, H-Arg-Arg-Nal-Cys-Tyr-Cit-Lys-D-Cit-Pro-Tyr-Arg-Cit-Cys-Arg-NH2 (S–S bridged), TFA, R-R-Nal-C-Y-Cit-K-(D)Cit-P-Y-R-Cit-C-R-NH2 (S–S bridged), TFA, where Nal=L-3-(2-naphthylalanine)
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关于此项目
NACRES:
NA.77
UNSPSC Code:
51111800
Assay:
≥95% (HPLC)
Form:
powder
Biochem/physiol Actions
CXCR4 antagonist and CXCR7 agonist that inhibits CXCR4-mediated HIV infection in cultures and ameliorates bleomycin-induced lung injury in vivo.
TC14012 is a highly stable and non-cytotoxic disulfide-bridged peptide with potent CXCR7 agonist and CXCR4 antagonist activity. TC14012 potently inhibits dual-tropic HIV strain 89.6 infection of CXCR4-expressing U87 glioblastoma cells (IC50 = 19.3 nM) and protects MT-4 cells against HIV-induced cytopathogenicity (EC50 = 0.4 nM). TC14012 also exhibits potent CXCR7-agonizing activity (HEK293T β-Arrestin recruitment EC50 = 350 nM; EC50 = 30 nM with CXCL12/SDF-1 and 140 μM with AMD3100). TC14012 (10 mg/kg i.t.) is efficacious in reducing repetitive bleomycin injections-induced collagen deposition and alveolar epithelial damage in a murine model of lung injury in vivo.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable