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Merck
CN

SML3384

Sigma-Aldrich

Cyclovirobuxine D

≥90% (HPLC)

别名:

(3α,5α,16α,20S)-4,4,14-Trimethyl-3,20-bis(methylamino)-9,19-cyclopregnan-16-ol, (3β,5α,16α,20S)-4,4,14-trimethyl-3,20-bis(methylamino)-9,19-cyclopregnan-16-ol, Bebuxine, CVB-D

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关于此项目

经验公式（希尔记法）:
C26H46N2O
CAS Number:
860-79-7
分子量:
402.66
MDL编号:
MFCD00468040
UNSPSC代码:
51111800
NACRES:
NA.77

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质量水平

100

方案

≥90% (HPLC)

表单

powder

颜色

white to beige

溶解性

0.1 M HCl: 2 mg/mL, clear

储存温度

-10 to -25°C

SMILES字符串

C[C@H](NC)[C@@]1([H])[C@H](O)C[C@@]2(C)[C@]3([H])CC[C@@]4([H])C(C)(C)[C@@H](NC)CC[C@]4(C5)[C@]35CC[C@@]21C

InChI

1S/C26H46N2O/c1-16(27-6)21-17(29)14-24(5)19-9-8-18-22(2,3)20(28-7)10-11-25(18)15-26(19,25)13-12-23(21,24)4/h16-21,27-29H,8-15H2,1-7H3/t16-,17+,18-,19-,20-,21-,23+,24-,25+,26-/m0/s1

InChI key

GMNAPBAUIVITMI-ABNIRSKTSA-N

生化/生理作用

Cyclovirobuxine D is a steroidal alkaloid component extracted from the root of medical plant Buxus microphylla that exhibits beneficial effect on heart failure, arrhythmias, myocardial ischemia and other cardiovascular diseases. Apparently it increases the release and uptake of Ca(2+) in systolic and diastolic periods. Cyclovirobuxine D induces mitochondria-mediated apoptosis in numerous cancer cells including breast and gastric cancer cells. It induces autophagy-associated cell death via the Akt/mTOR pathway in human breast cancer cells.
Steroidal alkaloid component extracted from the root of medical plant Buxus microphylla that exhibits beneficial effect on cardiovascular diseases

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000200626
0000200625
0000189954
0000189954
0000200626

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Hanmei Wei et al.
Journal of nanoscience and nanotechnology, 18(8), 5274-5282 (2018-02-21)
The blood-brain barrier (BBB) restricts the delivery of most drugs to the brain. In our previous study, the feasibility of cyclovirobuxine D delivery to the brain by a non-invasive nasal route was evaluated. In this study, a suitable drug delivery
Bin Yu et al.
Fitoterapia, 83(8), 1653-1665 (2012-10-02)
Our previous studies have shown that cyclovirobuxine D (CVB-D) ameliorated the cardiac function in heart failure rats. Considering the relationship between cardiac function and [Ca(2+)]i, and the role of calcium cycling on regulating [Ca(2+)]i, the present study was designed to
Jie Wu et al.
Molecules (Basel, Switzerland), 20(11), 20659-20668 (2015-11-28)
Gastric cancer is one of the most common malignant cancers, with high death rates, poor prognosis and limited treatment methods. Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. In the present study, we

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