SML3418
Xanthatin
≥98% (HPLC)
别名:
(-)-Xanthatin, (3aR,7S,8aS)-3,3a,4,7,8,8a-hexahydro-7-methyl-3-methylene-6-[(1E)-3-oxo-1-buten-1-yl]-2H-cyclohepta[b]furan-2-one, CID 5281511
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关于此项目
经验公式（希尔记法）:
C15H18O3
化学文摘社编号:
分子量:
246.30
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
O1[C@@H]2[C@H](CC=C([C@H](C2)C)\C=C\C(=O)C)C(=C)C1=O
InChI
1S/C15H18O3/c1-9-8-14-13(11(3)15(17)18-14)7-6-12(9)5-4-10(2)16/h4-6,9,13-14H,3,7-8H2,1-2H3/b5-4+/t9-,13+,14-/m0/s1
InChI key
RBRPTFMVULVGIC-ZTIIIDENSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Potent anticancer agent that induces cell cycle arrest at the G2/M phase.
Xanthatin, a sesquiterpene lactone isolated from Xanthium plants (Asteraceae), is a potent anticancer agent that induces cell cycle arrest at the G2/M phase in hepatocellular carcinoma and colon cancer cells. Xanthatin induces apoptosis in numerous cancer cell lines including colon, breast, lung, cervix, and skin cancers, while apparently spearing human normal LO2 hepatocytes. It appears to activate endoplasmic reticulum stress through activation of the PERK/eIF-2α/ATF4 axis in hepatocellular carcinoma cells. Also, xanthatin exhibit potent phytotoxic activity, which suppressed root growth of receiver plants.
Xanthatin, a sesquiterpene lactone isolated from Xanthium plants (Asteraceae), is a potent anticancer agent that induces cell cycle arrest at the G2/M phase in hepatocellular carcinoma and colon cancer cells. Xanthatin induces apoptosis in numerous cancer cell lines including colon, breast, lung, cervix, and skin cancers, while apparently spearing human normal LO2 hepatocytes. It appears to activate endoplasmic reticulum stress through activation of the PERK/eIF-2α/ATF4 axis in hepatocellular carcinoma cells. Also, xanthatin exhibit potent phytotoxic activity, which suppressed root growth of receiver plants.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Phytotoxic Compounds Isolated from Leaves of the Invasive Weed Xanthium spinosum
Molecules (Basel), 23(11), 2840-2840 (2018)
Xanthatin induces apoptosis by activating endoplasmic reticulum stress in hepatoma cells
European Journal of Pharmacology, 843, 1-11 (2019)
Assessment of the taste interaction between two qualitatively similar-tasting substances: a comparison between comparison rules
Journal of Experimental Psychology. General, 14(3), 526-538 (1988)
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