SML3513
Lorcaserin hydrochloride
≥98% (HPLC), 5-hydroxytryptamine receptor agonist, powder
别名:
(1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine hydrochloride, (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride, (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride, APD 356 hydrochloride, APD-356 hydrochloride, APD356 hydrochloride
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C11H14ClN·HCl
化学文摘社编号:
分子量:
232.15
UNSPSC Code:
12352200
NACRES:
NA.04
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
产品名称
Lorcaserin hydrochloride, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
drug control
USDEA Schedule IV
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Lorcaserin is an orally active, potent and selective 5-hydroxytryptamine receptor (5-HT2C) agonist (human/rat Ki = 15 /29 nM) with 18- and 104-fold higher potency than 5-HT2A and 5-HT2B by cellular inositol phosphate accumulation assay (EC50 = 9, 168, 943 nM, respectively) and good selectivity over 5-HT1A/3/4C/5A/6/7 and a panel of 67 other GPCRs and ion channels. Chronic daily treatment to rats (4.5-18 mg/kg p.o. b.i.d.) maintained on a high fat diet causes reductions in food intake and body weight gain.
Orally active, potent and selective 5-hydroxytryptamine receptor (5-HT2C) agonist in vitro and in vivo.
Disclaimer
Hygroscopic
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable