SML3610
Gingerenone A
≥95% (HPLC)
别名:
(4E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-4-Hepten-3-one, (E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hept-4-en-3-one
相关类别
生化/生理作用
Gingerenone A is a potent anticancer agent isolated from Ginger (Zingiber officinale) that exhibits minimal toxicity toward normal cells. Gingerenone A potently inhibits JAK2 (Janus Kinase 2) and S6K1 (p70 ribosomal S6 kinase). Gingerenone A significantly suppressed tumor growth in vivo. Also, it exhibits promising senolytic properties. Gingerenone A selectively eliminate senescent cells in WI-38 human fibroblasts rendered senescent by exposure to ionizing radiation.
JAK2 and S6K1inhibitor; anticancer agent isolated from Ginger; it exhibits promising senolytic properties.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Tzu-Jung Yu et al.
Antioxidants (Basel, Switzerland), 11(3) (2022-03-26)
Ginger is a popular spice and consists of several bioactive antioxidant compounds. Gingerenone A (Gin A), a novel compound isolated from Zingiber officinale, is rarely investigated for its anti-breast-cancer properties. Some ginger extracts have been reported to initiate senescence, an
Sanguine Byun et al.
The Journal of biological chemistry, 290(39), 23553-23562 (2015-08-06)
Bioactive phytochemicals can suppress the growth of malignant cells, and investigation of the mechanisms responsible can assist in the identification of novel therapeutic strategies for cancer therapy. Ginger has been reported to exhibit potent anti-cancer effects, although previous reports have
Identification of gingerenone A as a novel senolytic compound
PLoS ONE, 17(3), e0266135-e0266135 (2022)
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