SML3665
Palosuran
≥98% (HPLC)
别名:
1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea, CT-058362
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关于此项目
经验公式（希尔记法）:
C25H30N4O2
化学文摘社编号:
分子量:
418.53
UNSPSC Code:
12352200
NACRES:
NA.25
MDL number:
SMILES string
N3(CCC(CC3)(O)Cc4ccccc4)CCNC(=O)Nc1c2c(nc(c1)C)cccc2
InChI
1S/C25H30N4O2/c1-19-17-23(21-9-5-6-10-22(21)27-19)28-24(30)26-13-16-29-14-11-25(31,12-15-29)18-20-7-3-2-4-8-20/h2-10,17,31H,11-16,18H2,1H3,(H2,26,27,28,30)
InChI key
WYJCYXOCHXWTHG-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Orally available, potent, and selective noncompetitive urotensin 2 receptor antagonist
Palosuran (ACT-058362) is an orally available, potent, and selective noncompetitive urotensin 2 receptor antagonist. Palosuran decreases serum glucose, cholesterol, and triglyceride levels and increases survival in a rat model of diabetes induced by streptozotocin.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Elif Cadirci et al.
Naunyn-Schmiedeberg's archives of pharmacology, 392(2), 135-145 (2018-10-26)
Sepsis is a life-threatening organ dysfunction condition response resulting in acute lung injury. Urotensin II (UII), an endogenous vasoactive peptide, is widely distributed in pulmonary, cardiovascular, central nervous, renal and metabolic systems, and especially in inflammatory regions. This study aimed
Martine Clozel et al.
The Journal of pharmacology and experimental therapeutics, 316(3), 1115-1121 (2005-11-04)
Urotensin-II (U-II) is a cyclic peptide that acts through a specific G-protein-coupled receptor, UT receptor. Urotensin-II and UT receptors have been described in pancreas and kidney, but their function is not well understood. We studied the effects of chronic treatment
Martine Clozel et al.
The Journal of pharmacology and experimental therapeutics, 311(1), 204-212 (2004-05-18)
Urotensin-II (U-II) is a cyclic peptide now described as the most potent vasoconstrictor known. U-II binds to a specific G protein-coupled receptor, formerly the orphan receptor GPR14, now renamed urotensin receptor (UT receptor), and present in mammalian species. Palosuran (ACT-058362;
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