SML3665
Palosuran
≥98% (HPLC)
别名:
1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea, CT-058362
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
-10 to -25°C
SMILES字符串
N3(CCC(CC3)(O)Cc4ccccc4)CCNC(=O)Nc1c2c(nc(c1)C)cccc2
InChI
1S/C25H30N4O2/c1-19-17-23(21-9-5-6-10-22(21)27-19)28-24(30)26-13-16-29-14-11-25(31,12-15-29)18-20-7-3-2-4-8-20/h2-10,17,31H,11-16,18H2,1H3,(H2,26,27,28,30)
InChI key
WYJCYXOCHXWTHG-UHFFFAOYSA-N
生化/生理作用
Orally available, potent, and selective noncompetitive urotensin 2 receptor antagonist
Palosuran (ACT-058362) is an orally available, potent, and selective noncompetitive urotensin 2 receptor antagonist. Palosuran decreases serum glucose, cholesterol, and triglyceride levels and increases survival in a rat model of diabetes induced by streptozotocin.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Elif Cadirci et al.
Naunyn-Schmiedeberg's archives of pharmacology, 392(2), 135-145 (2018-10-26)
Sepsis is a life-threatening organ dysfunction condition response resulting in acute lung injury. Urotensin II (UII), an endogenous vasoactive peptide, is widely distributed in pulmonary, cardiovascular, central nervous, renal and metabolic systems, and especially in inflammatory regions. This study aimed
Martine Clozel et al.
The Journal of pharmacology and experimental therapeutics, 316(3), 1115-1121 (2005-11-04)
Urotensin-II (U-II) is a cyclic peptide that acts through a specific G-protein-coupled receptor, UT receptor. Urotensin-II and UT receptors have been described in pancreas and kidney, but their function is not well understood. We studied the effects of chronic treatment
Martine Clozel et al.
The Journal of pharmacology and experimental therapeutics, 311(1), 204-212 (2004-05-18)
Urotensin-II (U-II) is a cyclic peptide now described as the most potent vasoconstrictor known. U-II binds to a specific G protein-coupled receptor, formerly the orphan receptor GPR14, now renamed urotensin receptor (UT receptor), and present in mammalian species. Palosuran (ACT-058362;
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