SML3691
Anagrelide analog A6
≥98% (HPLC)
别名:
6-Chloro-1,5-dihydro-7-(4-methylphenyl)imidazo[2,1-b]quinazolin-2(3H)-one
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Anagrelide analog A6 is a cell penetrant and potent apoptosis inducer that works as a molecular glue bringing together phosphodiesterase 3A (PDE3A) and Schlafen 12 protein (SLFN12) forming heterotetrametric complex. Apparently, anagrelide analog A6 binds to the PDE3A enzymatic pocket that allows recruitment and stabilization of SLFN12, which in turn blocks protein translation, leads to apoptosis. It exhibits potent anticancer activity in cell cultures and in a tumor xenograft model.
Cell penetrant and potent apoptosis inducer that works as a molecular glue bringing together phosphodiesterase 3A (PDE3A) and Schlafen 12 protein (SLFN12)
signalword
Warning
hcodes
Hazard Classifications
Repr. 2 - STOT RE 2
target_organs
Cardiovascular
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Jie Chen et al.
Nature communications, 12(1), 6204-6204 (2021-10-29)
Molecular glues are a class of small molecular drugs that mediate protein-protein interactions, that induce either the degradation or stabilization of target protein. A structurally diverse group of chemicals, including 17-β-estradiol (E2), anagrelide, nauclefine, and DNMDP, induces apoptosis by forming
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