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Merck
CN

SML3691

Sigma-Aldrich

Anagrelide analog A6

≥98% (HPLC)

别名:

6-Chloro-1,5-dihydro-7-(4-methylphenyl)imidazo[2,1-b]quinazolin-2(3H)-one

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关于此项目

经验公式(希尔记法):
C17H14ClN3O
化学文摘社编号:
分子量:
311.77
UNSPSC代码:
12352200
NACRES:
NA.77
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质量水平

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

生化/生理作用

Anagrelide analog A6 is a cell penetrant and potent apoptosis inducer that works as a molecular glue bringing together phosphodiesterase 3A (PDE3A) and Schlafen 12 protein (SLFN12) forming heterotetrametric complex. Apparently, anagrelide analog A6 binds to the PDE3A enzymatic pocket that allows recruitment and stabilization of SLFN12, which in turn blocks protein translation, leads to apoptosis. It exhibits potent anticancer activity in cell cultures and in a tumor xenograft model.
Cell penetrant and potent apoptosis inducer that works as a molecular glue bringing together phosphodiesterase 3A (PDE3A) and Schlafen 12 protein (SLFN12)

象形图

Health hazard

警示用语:

Warning

危险声明

危险分类

Repr. 2 - STOT RE 2

靶器官

Cardiovascular

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Jie Chen et al.
Nature communications, 12(1), 6204-6204 (2021-10-29)
Molecular glues are a class of small molecular drugs that mediate protein-protein interactions, that induce either the degradation or stabilization of target protein. A structurally diverse group of chemicals, including 17-β-estradiol (E2), anagrelide, nauclefine, and DNMDP, induces apoptosis by forming

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