SML3776
AZD1080
≥98% (HPLC)
别名:
2-Hydroxy-3-[5-(4-morpholinylmethyl)-2-pyridinyl]-1H-indole-5-carbonitrile, 2-Hydroxy-3-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]-1H-indole-5-carbonitrile, AZ1080, AZD 1080
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关于此项目
经验公式（希尔记法）:
C19H18N4O2
化学文摘社编号:
分子量:
334.37
UNSPSC Code:
12352200
NACRES:
NA.21
MDL number:
SMILES string
N4(CCOCC4)Cc1cnc(cc1)c2c3c([nH]c2O)ccc(c3)C#N
InChI
1S/C19H18N4O2/c20-10-13-1-3-16-15(9-13)18(19(24)22-16)17-4-2-14(11-21-17)12-23-5-7-25-8-6-23/h1-4,9,11,22,24H,5-8,12H2
InChI key
BLTVBQXJFVRPFK-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
, Faint yellow to yellow brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
AZ1080 is a brain penetrant, orally bioavailable, potent and selective glycogen synthase kinase (GSK3) inhibitor that reduce pcdc1 (PD-1) transcription and expression. AZ1080 enhances CD8+ T-cell function in cancer, and is as effective as ant-PD-1 in controlling of B16 melanoma and EL4 lymphoma growth in mice.
Brain penetrant, orally bioavailable, potent and selective glycogen synthase kinase (GSK3) inhibitor that reduce pcdc1 (PD-1) transcription and expression
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Laura Caberlotto et al.
Naunyn-Schmiedeberg's archives of pharmacology, 386(10), 893-903 (2013-06-25)
Glycogen synthase kinase (GSK3) is a constitutively active serine-threonine kinase associated to neurological and psychiatric disorders. GSK3 inhibition is considered a mediator of the efficacy of the mood-stabiliser lithium. This study aimed at comparing the central nervous system effect of
Alison Taylor et al.
Cancer research, 78(3), 706-717 (2017-10-22)
The impact of PD-1 immune checkpoint therapy prompts exploration of other strategies to downregulate PD-1 for cancer therapy. We previously showed that the serine/threonine kinase, glycogen synthase kinase, GSK-3α/β, is a central regulator of PD-1 transcription in CD8+ T cells.
Shanshan Hu et al.
Neuropsychiatric disease and treatment, 16, 651-663 (2020-03-19)
Parkinson's disease (PD) is the second most common neurodegenerative disease. The α-Synuclein is a major component of Lewy bodies and Lewy neurites, the pathologic hallmark of PD. It is known that α-Synuclein is phosphorylated (p-α-Synuclein) in PD and tau-hyperphosphorylation (p-Tau)
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