SML3926
YM-53601 hydrochloride
≥98% (HPLC)
别名:
(E)-2-[2-fluoro-2-(quinuclidin-3-ylidene) ethxy]-9H-carbazole monohydrochloride, 2-[(2E)-2-(1-Azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole hydrochloride, YM 53601
相关类别
生化/生理作用
Squalene synthase inhibitor.
YM-53601 is a cell penetrant and potent squalene synthase inhibitor inhibits cholesterol biosynthesis in rodents. YM-53601 lowers cholesterol levels and triglyceride levels better than HMG-CoA reductase inhibitor (prevastatin) and fibrate (fenofibrate.).
YM-53601 is a cell penetrant and potent squalene synthase inhibitor inhibits cholesterol biosynthesis in rodents. YM-53601 lowers cholesterol levels and triglyceride levels better than HMG-CoA reductase inhibitor (prevastatin) and fibrate (fenofibrate.).
免责声明
Hygroscopic
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
T Ugawa et al.
British journal of pharmacology, 131(1), 63-70 (2000-08-26)
The aim of this study was to evaluate the potency of YM-53601 ((E)-2-[2-fluoro-2-(quinuclidin-3-ylidene) ethoxy]-9H-carbazole monohydrochloride), a new inhibitor of squalene synthase, in reducing both plasma cholesterol and triglyceride levels, compared with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor and fibrates, respectively.
Kyoko Saito et al.
Journal of virology, 89(4), 2220-2232 (2014-12-05)
Hepatitis C virus (HCV) exploits host membrane cholesterol and its metabolism for progeny virus production. Here, we examined the impact of targeting cellular squalene synthase (SQS), the first committed enzyme for cholesterol biosynthesis, on HCV production. By using the HCV
Yasushi Takemoto et al.
Journal of the American Chemical Society, 142(3), 1142-1146 (2020-01-04)
We accidentally found that YM-53601, a known small-molecule inhibitor of squalene synthase (SQS), selectively depletes SQS from mammalian cells upon UV irradiation. Further analyses indicated that the photodepletion of SQS requires its short peptide segment located at the COOH terminus.
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