SML4058
Florfenicol
≥98% (HPLC)
别名:
(-)-Florfenicol, 2,2-Dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide, 2,2-Dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide, SCH 25298
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关于此项目
经验公式（希尔记法）:
C12H14Cl2FNO4S
化学文摘社编号:
分子量:
358.21
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.21
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
ClC(C(N[C@@H]([C@H](O)C1=CC=C(S(C)(=O)=O)C=C1)CF)=O)Cl
InChI
1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1
InChI key
AYIRNRDRBQJXIF-NXEZZACHSA-N
Biochem/physiol Actions
Broad-spectrum antibiotic that inhibits protein synthesis by binding to the 50S ribosomal subunit of bacteria.
Florfenicol is a broad-spectrum antibiotic that is primarily used in veterinary medicine to treat respiratory infections in cattle and swine, and to prevent Salmonella infection in poultry. It has favorable ADME properties and is a fluorinated analog of chloramphenicol that has good tissue penetration and is resistant to chloramphenicol acetyltransferase inactivation. Florfenicol inhibits ribosomal activity and effectively inhibits bacterial protein synthesis, which makes it effective against various bacteria. However, oral administration of florfenicol may alter animal microbiota.
Florfenicol is a broad-spectrum antibiotic that is primarily used in veterinary medicine to treat respiratory infections in cattle and swine, and to prevent Salmonella infection in poultry. It has favorable ADME properties and is a fluorinated analog of chloramphenicol that has good tissue penetration and is resistant to chloramphenicol acetyltransferase inactivation. Florfenicol inhibits ribosomal activity and effectively inhibits bacterial protein synthesis, which makes it effective against various bacteria. However, oral administration of florfenicol may alter animal microbiota.
signalword
Danger
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 1
target_organs
Liver,Brain,Testes,Spinal cord,Blood,gallbladder
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Xingying Guo et al.
Environmental research, 244, 117934-117934 (2023-12-19)
Florfenicol, as a replacement for chloramphenicol, can tightly bind to the A site of the 23S rRNA in the 50S subunit of the 70S ribosome, thereby inhibiting protein synthesis and bacterial proliferation. Due to the widespread use in aquaculture and
P S Gaunt et al.
Journal of veterinary pharmacology and therapeutics, 36(5), 502-506 (2012-08-14)
Plasma disposition of florfenicol in channel catfish was investigated after an oral multidose (10 mg/kg for 10 days) administration in freshwater at water temperatures ranging from 24.7 to 25.9 °C. Florfenicol concentrations in plasma were analyzed by means of liquid
V P Syriopoulou et al.
Antimicrobial agents and chemotherapy, 19(2), 294-297 (1981-02-01)
We evaluated the in vitro antimicrobial activity of Sch 24893, Sch 25298, and Sch 25393, three novel analogs of chloramphenicol and thiamphenicol. All of the analogs had minimal inhibitory concentrations of less than or equal to 10 micrograms/ml for 18
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML4058-100MG | 04065271016293 |