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Merck
CN

SML4058

Sigma-Aldrich

Florfenicol

≥98% (HPLC)

别名:

(-)-Florfenicol, 2,2-Dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide, 2,2-Dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide, SCH 25298

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关于此项目

经验公式（希尔记法）:
C12H14Cl2FNO4S
化学文摘社编号:
73231-34-2
分子量:
358.21
MDL编号:
MFCD20926274
UNSPSC代码:
12352200

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质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

-10 to -25°C

SMILES字符串

ClC(C(N[C@@H]([C@H](O)C1=CC=C(S(C)(=O)=O)C=C1)CF)=O)Cl

InChI

1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1

InChI key

AYIRNRDRBQJXIF-NXEZZACHSA-N

相关类别

生化/生理作用

Broad-spectrum antibiotic that inhibits protein synthesis by binding to the 50S ribosomal subunit of bacteria.



Florfenicol is a broad-spectrum antibiotic that is primarily used in veterinary medicine to treat respiratory infections in cattle and swine, and to prevent Salmonella infection in poultry. It has favorable ADME properties and is a fluorinated analog of chloramphenicol that has good tissue penetration and is resistant to chloramphenicol acetyltransferase inactivation. Florfenicol inhibits ribosomal activity and effectively inhibits bacterial protein synthesis, which makes it effective against various bacteria. However, oral administration of florfenicol may alter animal microbiota.

象形图

Health hazardEnvironment
GHS08,GHS09

警示用语：

Danger

危险声明

H361fd,H372,H410

危险分类

Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 1

靶器官

Liver,Brain,Testes,Spinal cord,Blood,gallbladder

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

涉药品监管产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000497123
0000497123
0000493183
0000493183
0000465994

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P S Gaunt et al.
Journal of veterinary pharmacology and therapeutics, 36(5), 502-506 (2012-08-14)
Plasma disposition of florfenicol in channel catfish was investigated after an oral multidose (10 mg/kg for 10 days) administration in freshwater at water temperatures ranging from 24.7 to 25.9 °C. Florfenicol concentrations in plasma were analyzed by means of liquid
Xingying Guo et al.
Environmental research, 244, 117934-117934 (2023-12-19)
Florfenicol, as a replacement for chloramphenicol, can tightly bind to the A site of the 23S rRNA in the 50S subunit of the 70S ribosome, thereby inhibiting protein synthesis and bacterial proliferation. Due to the widespread use in aquaculture and
V P Syriopoulou et al.
Antimicrobial agents and chemotherapy, 19(2), 294-297 (1981-02-01)
We evaluated the in vitro antimicrobial activity of Sch 24893, Sch 25298, and Sch 25393, three novel analogs of chloramphenicol and thiamphenicol. All of the analogs had minimal inhibitory concentrations of less than or equal to 10 micrograms/ml for 18

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