SML4064
Ac-Abu-Tle-Leu-Gln-AFC
≥95% (HPLC)
别名:
Ac-Abu-Tle-LQ-AFC (Abu=2-Aminobutyrate, Tle=t-Butylglycine, AFC = 4-trifluoromethylcoumaryl-7-amide), Ac-QS1-AFC, Acetyl-L-α-aminobutyroyl-L-tert-leucyl-L-leucyl-L-glutamine-α-(4-trifluoromethylcoumaryl-7-amide)
质量水平
方案
≥95% (HPLC)
表单
(Powder or Lyophilized powder or film)
储存条件
desiccated
颜色
white to off-white
储存温度
-10 to -25°C
SMILES字符串
CC(N[C@H](C(N[C@H](C(C[C@H](C(N[C@H](C(NC1=CC2=C(C=C1)C(C(F)(F)F)=CC(O2)=O)=O)CCC(N)=O)=O)CC(C)C)=O)C(C)(C)C)=O)CC)=O
InChI
1S/C34H46F3N5O8/c1-8-23(39-18(4)43)31(48)42-29(33(5,6)7)25(44)14-19(13-17(2)3)30(47)41-24(11-12-27(38)45)32(49)40-20-9-10-21-22(34(35,36)37)16-28(46)50-26(21)15-20/h9-10,15-17,19,23-24,29H,8,11-14H2,1-7H3,(H2,38,45)(H,39,43)(H,40,49)(H,41,47)(H,42,48)/t19
InChI key
VWVFVJSQWAXHGY-RYRALHHHSA-N
生化/生理作用
Ac-QS1-AFC or Ac-Abu-Tle-Leu-Gln-AFC (Abu = Aminobutyrate; Tle = t-Butylglycine; AFC= 7-amino-4-trifluoromethyl coumarin) is a kinetically preferred fluorogenic substrate for the detection of SARS-CoV and SARS-CoV-2 main protease (Mpro; 3CLpro) activity. Mpro cleavage results in the release of the C-terminal AFC and increased fluorescence (ex 380+/-20 nm, em 500+/-20 nm).
免责声明
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
历史批次信息供参考:
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