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Merck
CN

SML4067

MCLA Hydrochloride

≥98% (HPLC)

别名:

2-Methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3-one HCl, 3,7-Dihydro-2-methyl-6-(4-methoxyphenyl)imidazol[1,2-a]pyrazine-3-one HCl, 6-(4-Methoxyphenyl)-2-methyl-3,7-dihydroimidazo[1,2-a]pyrazin-3-one HCl, 6-(4-Methoxyphenyl)-2-methylimidazo[1,2-a]pyrazin-3(7H)-one hydrochloride, MCLA HCl

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经验公式(希尔记法):
C14H14ClN3O2
化学文摘社编号:
分子量:
291.73
MDL number:
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
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SMILES string

O=C1C(C)=NC2=CNC(C3=CC=C(OC)C=C3)=CN21.Cl

assay

≥98% (HPLC)

form

powder

color

, Faint yellow to very dark orange

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

Quality Level

Biochem/physiol Actions

Chemiluminescence probe, after glow substrate, known for its high sensitivity in detecting reactive oxygen species like superoxide anion and singlet oxygen, both intracellularly and extracellularly.

MCLA (methoxylated Cypridina luciferin analog) is a highly sensitive probe employed in the detection of reactive oxygen species (ROS), particularly superoxide anion (O2•−) and singlet oxygen (1O2). It is notable for its blue luminescence (~ 455 nm), which is a critical indicator in ROS detection. MCLA′s detection mechanism involves oxidation to a probe radical, which then reacts with O2•− to produce luminescence. MCLA offers a broad dynamic range, making it versatile for both intracellular measurements in live cells and extracellular detection in various sample types. Its application is particularly significant in research related to oxidative stress, inflammation, and neurodegenerative diseases, where ROS play a pivotal role. Ex: ~ 430 nm, Em: ~ 549 nm.

Disclaimer

Hygroscopic

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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