Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
soluble (H2O + 1 drop 5M NaOH, 2 mg/mL, clear)
storage temp.
2-8°C
SMILES string
O=P(O)(C(P(O)(O)=O)NC1=NC=CC(OCCCCCC)=C1)O
Biochem/physiol Actions
Potent mevalonate (MVA) pathway farnesyl diphosphate synthase (FPPS) inhibitor that stimulates immune responses in vivo.
TH-Z93 is a potent farnesyl diphosphate synthase (FPPS) inhibitor (IC50 = 90 nM) that stimulates immune responses by blocking the mevalonate (MVA) pathway-mediated post-translational protein geranylgeranylation. When co-administered with antigen in mice in vivo, TH-Z93 triggers strong adjuvant responses, increasing OVA-specific antibody titres (in mice immunized with 100 μg OVA + 100 μg TH-Z93) and protects against death caused by live influenza virus PR8 challenge (in mice immunized with 5 μg PR8 HA1 subunit containing TH-Z93). TH-Z93 adjuvant efficacy is blocked by GGPP and synergized with HMG-CoA inhibitor simvastatin.
TH-Z93 is a potent farnesyl diphosphate synthase (FPPS) inhibitor (IC50 = 90 nM) that stimulates immune responses by blocking the mevalonate (MVA) pathway-mediated post-translational protein geranylgeranylation. When co-administered with antigen in mice in vivo, TH-Z93 triggers strong adjuvant responses, increasing OVA-specific antibody titres (in mice immunized with 100 μg OVA + 100 μg TH-Z93) and protects against death caused by live influenza virus PR8 challenge (in mice immunized with 5 μg PR8 HA1 subunit containing TH-Z93). TH-Z93 adjuvant efficacy is blocked by GGPP and synergized with HMG-CoA inhibitor simvastatin.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable