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关于此项目
经验公式（希尔记法）:
C23H35N9O8S · xC2HF3O2
化学文摘社编号:
分子量:
597.64 (free base basis)
NACRES:
NA.21
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
(Powder or Lyophilized powder or film)
Storage condition:
desiccated
Quality Segment
assay
≥95% (HPLC)
form
(Powder or Lyophilized powder or film)
storage condition
desiccated
color
white to off-white
storage temp.
-10 to -25°C
SMILES string
O=C([C@H]1N(C(C)=O)CCC1)N[C@@H](CC2=CN=CN2)C(N[C@@H](CO)C(N[C@@H](CS)C(N[C@@H](CC(N)=O)C(N)=O)=O)=O)=O
Application
ATN-161 trifluoroacetate salt may be used in studies focusing on angiogenesis and cancer research, particularly in the development of models assessing tumor growth and metastasis. It may also be used as a fluorescent probe in research to study cellular processes and interactions due to its ability to bind to integrins.
Biochem/physiol Actions
ATN-161, an antagonist of the integrin α5β1 receptor, is a non-RGD-based integrin binding peptide derived from the synergy region of fibronectin that inhibits the receptors for integrins alpha-v beta-3 and integrin alpha-5 beta-1. Integrin alpha-5 beta-1 is expressed on endothelial cells and plays a key role in endothelial cell adhesion and migration and may also play a key role in cancer cell invasion and metastasis. ATN-161 exhibits antiangiogenic and antitumor activity. This noncompetitive inhibitor of the fibronectin PHSRN sequence has the potential to disrupt the function of various integrins involved in tumor angiogenesis and metastasis. It can inhibit the interaction between the SARS-CoV-2 spike protein and its host binding partners.
Disclaimer
Hygroscopic
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable