SMILES string
O=C([C@@H]1N2[C@]([H])(S(=O)(C1(C)C)=O)CC2=O)O[Na]
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
-10 to -25°C
Application
Sulbactam sodium has been used for in vitro antibacterial efficacy analysis.
Biochem/physiol Actions
Sulbactam is a competitive, irreversible β-lactamase inhibitor enhancing β-lactam antibiotics′ efficacy. Sulbactam sodium, the sodium salt form of sulbactam is water-soluble and exhibits enhanced hydrophilicity and is better suited for formulations involving aqueous media. In its capacity as a β-lactamase inhibitor, sulbactam sodium synergistically augments the antimicrobial efficacy of β-lactam antibiotics against recalcitrant bacterial pathogens. This synergistic effect is achieved through an irreversible covalent interaction between sulbactam and the β-lactamase enzymes, which are responsible for the degradation and consequent inactivation of β-lactam antibiotics. Additionally, sulbactam sodium demonstrates inherent antibacterial activity, albeit with a relatively lower potency compared to other members of the β-lactam antibiotic class.
Disclaimer
Hygroscopic Store with desiccant
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