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Merck
CN

SML4181

Sulbactam sodium

new

≥98% (HPLC), powder, β-lactamase inhibitor

别名:

CP 45899-2, Sodium (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide, (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide sodium salt, Penicillanic acid 1,1-dioxide sodium salt, Sodium 1,1-dioxypenicillanate, Sodium penicillanate 1,1-dioxide

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关于此项目

经验公式(希尔记法):
C8H11NO5SNa
化学文摘社编号:
分子量:
256.23
MDL编号:
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质量水平

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to beige

溶解性

H2O: 2 mg/mL, clear

储存温度

-10 to -25°C

SMILES字符串

O=C([C@@H]1N2[C@]([H])(S(=O)(C1(C)C)=O)CC2=O)O[Na]

应用

Sulbactam sodium may be used for in vitro antibacterial efficacy analysis.

生化/生理作用

Sulbactam is a competitive, irreversible β-lactamase inhibitor that enhances β-lactam antibiotics′ efficacy.
Sulbactam sodium, the sodium salt form of sulbactam, is water-soluble and exhibits enhanced hydrophilicity and is better suited for formulations involving aqueous media. In its capacity as a β-lactamase inhibitor, sulbactam sodium synergistically augments the antimicrobial efficacy of β-lactam antibiotics against recalcitrant bacterial pathogens. This synergistic effect is achieved through an irreversible covalent interaction between sulbactam and the β-lactamase enzymes, which are responsible for the degradation and consequent inactivation of β-lactam antibiotics. Additionally, sulbactam sodium demonstrates inherent antibacterial activity, albeit with a relatively lower potency compared to other members of the β-lactam antibiotic class.

免责声明

Hygroscopic Store with desiccant

法规信息

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分析证书(COA)

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