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经验公式（希尔记法）:
C18H20FN3O4 · xHCl
化学文摘社编号:
分子量:
361.37 (free base basis)
MDL number:
NACRES:
NA.21
SMILES string
O=C1C2=CC(F)=C(C3=C2N([C@H](CO3)C)C=C1C(O)=O)N4CCN(C)CC4.[xHCl]
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
-10 to -25°C
General description
Levofloxacin is the L-isomer of the racemic fluoroquinolone, ofloxacin. It has a more intricate fused ring structure that is linked to the oxazinoquinoline core as compared to quinolones. Levofloxacin is a broad-spectrum fluoroquinolone antibiotic that exhibits high water solubility. While the hydrochloride form of levofloxacin is freely soluble in water, levofloxacin itself is only sparingly soluble in aqueous solutions.
Application
Levofloxacin hydrochloride may be used to:
- investigate its antibacterial effects against Gram-positive and Gram-negative bacteria
- assess environmental antibiotic pollution
- study drug–food interactions in pharmacokinetic research by evaluating the impact of dietary interventions on quinolone bioavailability
Biochem/physiol Actions
Levofloxacin is a fluoroquinolone antibiotic with broad-spectrum activity, the optical S-(-) isomer of ofloxacin, which kills bacteria by blocking DNA gyrase and type IV topoisomerase—critical enzymes for DNA replication and transcription—leading to cell death. It is effective against a broad array of both Gram-positive and Gram-negative bacteria, in addition to Mycoplasmas.
Disclaimer
Hygroscopic Store with desiccant
法规信息
新产品
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Agnieszka Wiesner et al.
Clinical pharmacokinetics, 63(6), 773-818 (2024-05-29)
Managing drug-food interactions is essential for optimizing the effectiveness and safety profile of quinolones. Following PRISMA guidelines, we systematically reviewed the influence of dietary interventions on the bioavailability of 22 quinolones. All studies describing or investigating the impact of food
Levofloxacin, a new quinolone antibacterial agent. An introductory overview.
I Hayakawa et al.
Arzneimittel-Forschung, 43(3A), 363-364 (1992-03-01)
Raizza Zorman Marques et al.
Environmental pollution (Barking, Essex : 1987), 357, 124376-124376 (2024-06-20)
We compared the ability of one emergent (Sagittaria montevidensis), two floating (Salvinia minima and Lemna gibba), and one heterophyllous species (Myriophyllum aquaticum) to simultaneously remove sulfamethoxazole, sulfadiazine, ciprofloxacin, enrofloxacin, norfloxacin, levofloxacin, oxytetracycline, tetracycline, doxycycline, azithromycin, amoxicillin, and meropenem from wastewater
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