SMILES string
OC1=C(C(O)=CC(CCCCC)=C1)C/C=C(C)/CCC=C(C)C
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Application
Cannabigerol may be used to study its binding properties to cannabinoid CB1 (CB1R) and CB2 (CB2R) receptors and its effects on agonist activation of those receptors and of CB1–CB2 heteroreceptor complexes.
Biochem/physiol Actions
Cannabigerol is a non-psychoactive phytocannabinoid. Cannabigerol binds CB1 and CB2 receptors with Ki values of 440 and 337 nM, respectively and acts as a partial agonist against CB1 and CB2 receptor subtypes. The compound is a potent a2-adrenoceptor agonist (EC50 = 0.2 nM). Cannabigerol modulates the expression of proinflammatory proteins, such as TNF-α, IL-1β, IL-6, IL-10, interferon-γ, and prostaglandin E2. CBG displays a broad spectrum of biological activities, including anti-inflammatory, antibacterial, and antifungal effects, as well as the regulation of redox balance and neuromodulatory properties.
法规信息
新产品
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Rahul Nachnani et al.
The Journal of pharmacology and experimental therapeutics, 376(2), 204-212 (2020-11-11)
Medical cannabis and individual cannabinoids, such as Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), are receiving growing attention in both the media and the scientific literature. The Cannabis plant, however, produces over 100 different cannabinoids, and cannabigerol (CBG) serves as the precursor
M G Cascio et al.
British journal of pharmacology, 159(1), 129-141 (2009-12-17)
Cannabis is the source of at least seventy phytocannabinoids. The pharmacology of most of these has been little investigated, three notable exceptions being Delta(9)-tetrahydrocannabinol, cannabidiol and Delta(9)-tetrahydrocannabivarin. This investigation addressed the question of whether the little-studied phytocannabinoid, cannabigerol, can activate
Agnieszka Gęgotek et al.
The Journal of pharmacology and experimental therapeutics, 387(2), 170-179 (2023-09-01)
Excessive daily exposure of human skin to natural UVA radiation leads to impaired redox homeostasis in epidermal keratinocytes, resulting in changes in their proteome. Commonly used antioxidants usually exhibit protection in a narrowed range, which makes it necessary to combine
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