SML4230
Cannabigerol
≥98% (HPLC)
别名:
2-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-5-pentyl-1,3-benzenediol, 2-((2E)-3,7-Dimethylocta-2,6-dienyl)-5-pentylbenzene-1,3-diol, CBG
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
-10 to -25°C
SMILES字符串
OC1=C(C(O)=CC(CCCCC)=C1)C/C=C(C)/CCC=C(C)C
生化/生理作用
Partial agonist against of cannabinoid receptors CB1 and CB2; non-psychotropic phytocannabinoid.
Cannabigerol is a non-psychoactive phytocannabinoid. Cannabigerol binds CB1 and CB2 receptors with Ki values of 440 and 337 nM, respectively and acts as a partial agonist against both receptor subtypes. The compound is a potent a2-adrenoceptor agonist (EC50 = 0.2 nM). Cannabigerol modulates the expression of expression of proinflammatory proteins, such as TNF-α, IL-1β, IL-6, IL-10, interferon-γ, and prostaglandin E2.
Cannabigerol is a non-psychoactive phytocannabinoid. Cannabigerol binds CB1 and CB2 receptors with Ki values of 440 and 337 nM, respectively and acts as a partial agonist against both receptor subtypes. The compound is a potent a2-adrenoceptor agonist (EC50 = 0.2 nM). Cannabigerol modulates the expression of expression of proinflammatory proteins, such as TNF-α, IL-1β, IL-6, IL-10, interferon-γ, and prostaglandin E2.
法规信息
新产品
此项目有
Rahul Nachnani et al.
The Journal of pharmacology and experimental therapeutics, 376(2), 204-212 (2020-11-11)
Medical cannabis and individual cannabinoids, such as Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), are receiving growing attention in both the media and the scientific literature. The Cannabis plant, however, produces over 100 different cannabinoids, and cannabigerol (CBG) serves as the precursor
Agnieszka Gęgotek et al.
The Journal of pharmacology and experimental therapeutics, 387(2), 170-179 (2023-09-01)
Excessive daily exposure of human skin to natural UVA radiation leads to impaired redox homeostasis in epidermal keratinocytes, resulting in changes in their proteome. Commonly used antioxidants usually exhibit protection in a narrowed range, which makes it necessary to combine
M G Cascio et al.
British journal of pharmacology, 159(1), 129-141 (2009-12-17)
Cannabis is the source of at least seventy phytocannabinoids. The pharmacology of most of these has been little investigated, three notable exceptions being Delta(9)-tetrahydrocannabinol, cannabidiol and Delta(9)-tetrahydrocannabivarin. This investigation addressed the question of whether the little-studied phytocannabinoid, cannabigerol, can activate
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