Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Application
GSK0660 may be used in cell viability assay, real time cell index analysis, and oxyblot assays to study its neuroprotective effect on Parkinson’s disease model in vivo and in vitro.
Biochem/physiol Actions
GSK0660 is a potent and selective peroxisome proliferator-activated receptor delta (PPARdelta) and PPARbeta antagonist (IC50 = 300 nM against GW1516-induced PPARβ/δ reporter activity; IC50 = 155 nM vs >10 µM for PPARα and PPARγ by GW1516 displacement binding assays). GSK0660 effectively antagonizes PPARβ/δ agonist GW501516 (GW1516)-induced target genes expression in multiple cell types, including HuH7, rat L6 myotubes, and mouse BMDMs (1-10 nM GW1516, 100-1000 nM GSK0660).
法规信息
新产品
此项目有
Bibimaryam Khan et al.
European journal of pharmacology, 972, 176565-176565 (2024-04-11)
Blockade of PD-1/PD-L1 immune checkpoint is wildly used for multiple types of cancer treatment, while the low response rate for patients is still completely unknown. As nuclear hormone receptor, PPARδ (peroxisome-proliferator-activated receptor) regulates cell proliferation, inflammation, and tumor progression, while
Andrea Antonosante et al.
Biological research, 56(1), 27-27 (2023-05-25)
The underlying mechanism of Parkinson's disease are still unidentified, but excitotoxicity, oxidative stress, and neuroinflammation are considered key actors. Proliferator activated receptors (PPARs) are transcription factors involved in the control of numerous pathways. Specifically, PPARβ/δ is recognized as an oxidative
Barry G Shearer et al.
Molecular endocrinology (Baltimore, Md.), 22(2), 523-529 (2007-11-03)
The identification of small molecule ligands for the peroxisome proliferator-activated receptors (PPARs) has been instrumental in elucidating their biological roles. In particular, agonists have been the focus of much of the research in the field with relatively few antagonists being
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持