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SML4244

GSK0660

Name: GSK0660
Brand: SIGMA

≥98% (HPLC), powder, PPARβ/δ antagonist

别名:

3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester, Methyl 3-({[2-(methoxy)-4 phenyl]amino}sulfonyl)-2-thiophenecarboxylate, GSK 0660, GSK-0660

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关于此项目

经验公式（希尔记法）:

C₁₉H₁₈N₂O₅S₂

化学文摘社编号:

1014691-61-2

分子量:

418.49

MDL number:

MFCD12828770

NACRES:

NA.21

UNSPSC Code:

12352200

Assay:

≥98% (HPLC)

Form:

powder

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属性

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

说明

Application

GSK0660 may be used in cell viability assay, real time cell index analysis, and oxyblot assays to study its neuroprotective effect on Parkinson’s disease model in vivo and in vitro.

Biochem/physiol Actions

GSK0660 is a potent and selective peroxisome proliferator-activated receptor delta (PPARdelta) and PPARbeta antagonist (IC50 = 300 nM against GW1516-induced PPARβ/δ reporter activity; IC50 = 155 nM vs >10 µM for PPARα and PPARγ by GW1516 displacement binding assays). GSK0660 effectively antagonizes PPARβ/δ agonist GW501516 (GW1516)-induced target genes expression in multiple cell types, including HuH7, rat L6 myotubes, and mouse BMDMs (1-10 nM GW1516, 100-1000 nM GSK0660).

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存储类别

11 - Combustible Solids

怎么回事？

WGK 2

闪点 (F)

No data available

闪点 (°C)

No data available

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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