SML4258
Spexin 1 trifluoroacetate
≥95% (HPLC)
别名:
H-Asn-Trp-Thr-Pro-Gln-Ala-Met-Leu-Tyr-Leu-Lys-Gly-Ala-Gln-NH₂ trifluoroacetate, L-Asparaginyl-L-tryptophyl-L-threonyl-L-prolyl-L-glutaminyl-L-alanyl-L-methionyl-L-leucyl-L-tyrosyl-L-leucyl-L-lysylglycyl-L-alanyl-L-glutamamide trifluoroacetate, Spexin trifluoroacetate, SPX trifluoroacetate, SPX1 trifluoroacetate, Neuropeptide Q trifluoroacetate, NPQ trifluoroacetate, NPQ 53-70 trifluoroacetate, NWTPQAMLYLKGAQ-NH2 trifluoroacetate
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关于此项目
经验公式（希尔记法）:
C74H114N20O19S · xC2HF3O2
化学文摘社编号:
分子量:
1619.88 (free base basis)
UNSPSC代码:
12352200
质量水平
方案
≥95% (HPLC)
表单
(Powder or Lyophilized powder or film)
储存条件
desiccated
颜色
white to off-white
储存温度
-10 to -25°C
一般描述
Endogenous galanin receptor GAL2/3 agonist with anti-obesity efficacy in cultures and in vivo.
Spexin 1 (SPX) is a 14-aa amidated peptide that acts as an endogenous galanin receptor GAL2/3 agonist (EC50 = 161 nM/GAL2, 626 nM/GAL3, >10 µM/GAL1 by reporter assays using respective HEK293 transfectants) that inhibits facilitated fatty acid (FA) uptake in diet-induced obesity (DIO) mouse adipocytes cultures (0.1-1 ng/mL) and induces rat stomach muscle contraction ex vivo (EC50 = 750 nM). SPX reduces caloric intake in rats (∼32%; 35 µg/kg/day s.c.) with corresponding weight loss and significantly reduces the RER at night as well as increases locomotion in mice in vivo (25 µg/kg/day i.p.). Note: peptide sequence is conserved in human, murine, rat and many other mammalian species.
Spexin 1 (SPX) is a 14-aa amidated peptide that acts as an endogenous galanin receptor GAL2/3 agonist (EC50 = 161 nM/GAL2, 626 nM/GAL3, >10 µM/GAL1 by reporter assays using respective HEK293 transfectants) that inhibits facilitated fatty acid (FA) uptake in diet-induced obesity (DIO) mouse adipocytes cultures (0.1-1 ng/mL) and induces rat stomach muscle contraction ex vivo (EC50 = 750 nM). SPX reduces caloric intake in rats (∼32%; 35 µg/kg/day s.c.) with corresponding weight loss and significantly reduces the RER at night as well as increases locomotion in mice in vivo (25 µg/kg/day i.p.). Note: peptide sequence is conserved in human, murine, rat and many other mammalian species.
免责声明
Hygroscopic Store with desiccant
法规信息
新产品
此项目有
José L Walewski et al.
Obesity (Silver Spring, Md.), 22(7), 1643-1652 (2014-02-20)
Microarray studies identified Ch12:orf39 (Spexin) as the most down-regulated gene in obese human fat. Therefore, we examined its role in obesity pathogenesis. Spexin effects on food intake, meal patterns, body weight, respiratory exchange ratio (RER), and locomotor activity were monitored
Olivier Mirabeau et al.
Genome research, 17(3), 320-327 (2007-02-08)
Peptide hormones are small, processed, and secreted peptides that signal via membrane receptors and play critical roles in normal and pathological physiology. The search for novel peptide hormones has been hampered by their small size, low or restricted expression, and
Dong-Kyu Kim et al.
Endocrinology, 155(5), 1864-1873 (2014-02-13)
The novel neuropeptide spexin (SPX) was discovered using bioinformatics. The function of this peptide is currently under investigation. Here, we identified SPX along with a second SPX gene (SPX2) in vertebrate genomes. Syntenic analysis and relocating SPXs and their neighbor
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