生物来源
human
重组
expressed in baculovirus infected Sf9 cells
方案
≥44% (SDS-PAGE)
表单
aqueous solution
分子量
65 kDa
包装
pkg of 50 μg
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... SESN1(27244)
一般描述
Human Sestrin1, also known as p53-regulated protein PA26 (GenBank Accession No. NM_014454) full length, amino acids 2-551(end) with N-terminal FLAG-tag, MW=65 kDa, expressed in Sf9 insect cells via a Baculovirus expression system.
应用
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
Broderick, G., et al.
The Pharmacogenomics Journal, 7, 407-419 (2006)
Jun Hee Lee et al.
Science (New York, N.Y.), 327(5970), 1223-1228 (2010-03-06)
Sestrins are conserved proteins that accumulate in cells exposed to stress, potentiate adenosine monophosphate-activated protein kinase (AMPK), and inhibit activation of target of rapamycin (TOR). We show that the abundance of Drosophila sestrin (dSesn) is increased upon chronic TOR activation
Andrei V Budanov et al.
Cell, 134(3), 451-460 (2008-08-12)
The tumor suppressor p53 is activated upon genotoxic and oxidative stress and in turn inhibits cell proliferation and growth through induction of specific target genes. Cell growth is positively regulated by mTOR, whose activity is inhibited by the TSC1:TSC2 complex.
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