SRP4028
Eotaxin human
recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)
别名:
CCL11, Eosinophil chemotactic protein chemokine (C-C motif) ligand 11, MGC22554, SCYA11, Small inducible cytokine A11
生物来源
human
重组
expressed in E. coli
方案
≥97% (HPLC)
≥97% (SDS-PAGE)
表单
lyophilized
效能
10 ng/mL
分子量
~8.3 kDa
包装
pkg of 20 μg
储存条件
avoid repeated freeze/thaw cycles
杂质
endotoxin, tested
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... CCL11(6356)
一般描述
Eotaxin is a chemokine and belongs to the Th2 (T helper 2) cytokine family. It is expressed in many organs, such as heart, central nervous system and the cerebrospinal fluid. The associated gene (CCL11 (C-C motif chemokine ligand 11)) is mapped to human chromosome 17q12.
生化/生理作用
Eotaxin participates in immunoregulatory and inflammatory responses. It works as a chemoattractant for many immune cells, including eosinophils, basophils, myeloid cells and T-helper 2 lymphocytes. The eotaxin gene is associated with atopic dermatitis, allergic rhinitis, sinusitis, asthma, ulcerative colitis, gastrointestinal disorders and parasitic infections. It is also involved with the pathogenesis of ovarian and gastric cancer. Eotaxin plays a significant role in the aging processes.
外形
Sterile filtered and Lyophilized without additives.
制备说明
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstituted in water to a concentration of 0.1-1 μg/μL. It is recommended that further dilutions be made into buffer containing carrier protein or medium containing serum.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Rossana C N Melo et al.
PloS one, 8(3), e59578-e59578 (2013-04-05)
Lipid bodies (LBs), also known as lipid droplets, are complex organelles of all eukaryotic cells linked to a variety of biological functions as well as to the development of human diseases. In cells from the immune system, such as eosinophils
Kimberly D Dyer et al.
PloS one, 10(3), e0118887-e0118887 (2015-03-17)
HMGB1 is an alarmin that can stimulate the innate immune system alone or in a complex with other inflammatory mediators. Given the recent interest in HMGB1 with respect to the pathogenesis of eosinophil-associated disorders, including asthmatic inflammation and chronic rhinosinusitis
Is Eotaxin-1 a serum and urinary biomarker for prostate cancer detection and recurrence?
Heidegger I, et al.
Prostate, 75, 1904-1904 (2015)
Mustafa Ahmadzai et al.
Frontiers in immunology, 6, 525-525 (2015-11-06)
Eosinophil migration to the lung is primarily regulated by the eosinophil-selective family of eotaxin chemokines, which mobilize intracellular calcium (Ca(2+)) and orchestrate myriad changes in cell structure and function. Eosinophil function is also known to be flow-dependent, although the molecular
Colonic eosinophilic inflammation in experimental colitis is mediated by Ly6C(high) CCR2(+) inflammatory monocyte/macrophage-derived CCL11.
Waddell A, et al.
Journal of Immunology, 186, 5993-5993 (2011)
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