SRP4244
MIP-1alpha human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
别名:
G0S19-1, LD78α, MIP-1-α, chemokine (C-C motif) ligand 3
生物来源
human
重组
expressed in E. coli
方案
≥98% (HPLC)
≥98% (SDS-PAGE)
表单
lyophilized
分子量
~7.8 kDa
包装
pkg of 20 μg
杂质
endotoxin, tested
NCBI登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... CCL3(6348)
一般描述
MIP-1α (microphage inflammatory protein-1α), or CCL3 (C-C motif chemokine ligand 3), was originally isolated from the supernatant of endotoxin-stimulated murine macrophages. It is an 8kDa chemokine; chemokines are a type of chemotactic cytokines.
生化/生理作用
MIP-1α (microphage inflammatory protein-1α), or CCL3 (C-C motif chemokine ligand 3), and its receptors- CCR1 and CCR5- promote tumor growth and control osteoclast differentiation, thereby contributing to bone disease progression in multiple myeloma. It suppresses the expression of miR-374b through JNK (Janus kinase), ERK (extracellular signal-regulated kinases), and p38 pathways, thus, facilitating VEGF-A (vascular endothelial growth factor) expression and angiogenesis in human osteosarcoma cells. In chondrosarcoma cells, this protein promotes the up-regulation of matrix metalloproteinase-2 (MMP)-2, thus, promoting cell migration and metastasis.
外形
Sterile filtered and then lyophilized without any additives.
制备说明
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can be diluted into other aqueous buffers.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1.
Zhang N et al
Proceedings of the National Academy of Sciences of the USA, 102(12), 4536-4541 (2005)
CCL3 promotes angiogenesis by dysregulation of miR-374b/ VEGF-A axis in human osteosarcoma cells.
Liao YY et al
Oncotarget, 7(4), 4310-4325 (2016)
Ping Shi et al.
Oncology reports, 34(3), 1319-1326 (2015-07-03)
In recent years, astrocyte elevated gene-1 (AEG-1) has been reported as a key mediator that is involved in the epithelial-to-mesenchymal transition (EMT) process. However, the mechanisms underlying CCL3/CCR5-AEG-1 pathway-mediated EMT in cardiac myxoma (CM) has not been well featured till
Inger Øynebråten et al.
PloS one, 9(8), e104814-e104814 (2014-08-15)
DNA vaccines based on subunits from pathogens have several advantages over other vaccine strategies. DNA vaccines can easily be modified, they show good safety profiles, are stable and inexpensive to produce, and the immune response can be focused to the
Katsuyuki Matsushita et al.
Anesthesiology, 120(6), 1491-1503 (2014-03-05)
The chemokine family has been revealed to be involved in the pathogenesis of neuropathic pain. In this study, the authors investigated the role of chemokine (C-C motif) ligand 3 and its receptors chemokine (C-C motif) receptor 1 and chemokine (C-C
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