BD-3 human

β-defensin-3 (BD-3) is an anti-microbial peptide produced by airway epithelial cells, lung-derived epithelial cells and keratinocytes. It has a molecular weight of 5kDa. The gene encoding this protein is localized on human chromosome 8p23.1. Recombinant human β-defensin-3 (BD-3) is an antimicrobial peptide, which belongs to the distinct family of β-defenisns. Recombinant human BD-3 is a 5.1 kDa protein containing 45 amino acid residues.

Chemical structure: peptide

β-defensin-3 (BD-3) associates with bacterial products which reduce the effect of inflammatory cytokine responses. The protein has been shown to stimulate the production of interferon-α and activate monocytes through toll-like receptors 1 and 2. It antagonizes the activation of C-X-C motif chemokine receptor 4 (CXCR4).

Sterile filtered and lyophilized with no additives.

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in 10 mM Acetic acid to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.