biological source
human
recombinant
expressed in E. coli
assay
≥98% (HPLC), ≥98% (SDS-PAGE)
form
lyophilized
mol wt
~32 kDa
packaging
pkg of 20 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... BMP10(27302)
General description
BMPs (bone morphogenetic proteins) belong to the TGF-β superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP-10 is essential for the proper development of the heart, but is not expressed until after cardiac patterning or looping are completed. Recombinant human BMP-10 is a 32 kDa disulfide-linked homodimer containing two 142 amino acid polypeptide chains.
The bone morphogenetic protein 10 (BMP10) gene spans ~7.8 kb on human chromosome 2p13.3. It is highly expressed in the trabeculae of the embryonic heart, but it is expressed at low levels in the liver and the lungs. BMP-10 belongs to the bone morphogenetic protein (BMP) family.
Biochem/physiol Actions
Bone morphogenetic protein 10 (BMP10) acts as a potent tumor suppressor in prostate, gastric and breast cancer. It is implicated in trabeculation of the embryonic heart. BMP10 retards the growth of prostate cancer cells via, apoptosis induced by X- inhibitor of apoptosis protein (XIAP) and extracellular signal–regulated kinase (ERK)1/2 dependent signaling and SMAD-independent signaling. In addition, it also has an ability to inhibit prostate cancer cell migration and invasiveness. Elevated expression of the gene inhibits growth, adhesion and migration of bladder cancer cells in vitro. Thus, this protein can be considered as a potent therapeutic target for bladder cancer.
Physical form
Sterile filtered and Lyophilized without additives.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute to a concentration of 0.1-1.0 mg/mL in water containing BSA (50 mg BSA per 1 mg of protein). This solution can then be diluted into other aqueous buffers
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
BMP10 inhibited the growth and migration of gastric cancer cells.
Lei H, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(3), 3025-3031 (2016)
TMEM100 expression suppresses metastasis and enhances sensitivity to chemotherapy in gastric cancer.
Jinfu Zhuang et al.
Biological chemistry, 401(2), 285-296 (2019-06-13)
The gene encoding transmembrane protein 100 (TMEM100) was first discovered to be transcribed by the murine genome. It has been recently proven that TMEM100 contributes to hepatocellular carcinoma and non-small-cell lung carcinoma (NSCLC). This study investigates the impact of TMEM100
Ning Zhang et al.
Anticancer research, 33(5), 1917-1925 (2013-05-07)
Bone morphogenetic protein-10 (BMP10), a novel member of the bone morphogenetic protein (BMP) family, has been indicated as a possible tumour suppressor in prostate and breast cancer. However, its role in urothelial tumours remains unknown. In the present study, we
Lijun Sun et al.
Journal of cellular biochemistry, 115(11), 1868-1876 (2014-06-07)
Heart disease is among the leading causes of death worldwide, and the limited proliferation of mammalian cardiomyocytes prevents heart regeneration in response to injury. Bone morphogenetic protein-10 (BMP10) exerts multiple roles in various developmental events; however, the effect of BMP10
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