SRP5215
SMYD3, GST tagged human
recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
别名:
FLJ21080, ZMYND1, ZNFN3A1
重组
expressed in baculovirus infected Sf9 cells
方案
≥70% (SDS-PAGE)
表单
buffered aqueous glycerol solution
分子量
~71 kDa
NCBI登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... SMYD3(64754)
一般描述
SMYD3 (SET and MYND domain containing 3) is a histone methyltransferase that plays a role in transcriptional regulation as a member of an RNA polymerase complex. The introduction of SMYD3 enhanced cell growth and the histone methyltransferase activity of SMYD3 involved in the proliferation of cancer cells. A variable number of tandems repeat polymorphism in an E2F-1 binding element in the 5-prime flanking region of SMYD3 is a risk factor for human cancers.
外形
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
制备说明
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Ryuji Hamamoto et al.
Nature cell biology, 6(8), 731-740 (2004-07-06)
Colorectal and hepatocellular carcinomas are some of the leading causes of cancer deaths worldwide, but the mechanisms that underly these malignancies are not fully understood. Here we report the identification of SMYD3, a gene that is over-expressed in the majority
Masataka Tsuge et al.
Nature genetics, 37(10), 1104-1107 (2005-09-13)
Histone modification is a crucial step in transcriptional regulation, and deregulation of the modification process is important in human carcinogenesis. We previously reported that upregulation of SMYD3, a histone methyltransferase, promoted cell growth in human colorectal and hepatocellular carcinomas. Here
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