SRP6039
Pro-MMP-13 human
recombinant, expressed in Sf9 cells, ≥95% (SDS-PAGE)
别名:
MMP recombinant, MMP13, Matrix metalloproteinase-13, procollagenase 3
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Form:
liquid
Assay:
≥95% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in Sf9 cells
Mol wt:
53.820 kDa
biological source
human
recombinant
expressed in Sf9 cells
assay
≥95% (SDS-PAGE)
form
liquid
mol wt
53.820 kDa
packaging
pkg of 10 μg
concentration
~100 μg/mL
impurities
Endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−70°C
Gene Information
human ... MMP13(4322)
General description
MMP13 (matrix metalloproteinase13) was first identified in 1994 in human breast cancer. It is produced as an inactive proenzyme, and is activated by the cleavage of its N-terminal region. MMPs constitute a single protein superfamily, which are further classified as collagenases, gelatinases, and stromelysins. Humans contain nine MMPs, and MMP13 is a member of the collagenases subfamily, and is also known as collagenase 3. MMP13 gene is localized to the human chromosome location 11q14.3–23.2, which houses the nine MMP genes.
Biochem/physiol Actions
MMP13 (matrix metalloproteinase13) functions against different types of ECM (extracellular matrix) components. It gets activated by and activates multiple MMPs, and hence, has a central role in the MMP cascade. This protein is frequently expressed in colorectal cancer (CRC), and this expression is linked with poor survival in CRC. MMP13 expression is absent in normal breast tissue, but is present in breast carcinoma suggesting its role in tumorigenesis. The expression of this protein can serve as a marker for tumor invasiveness, as its expression is induced during metastasis of multiple types of cancers, including squamous cell carcinomas of the head and neck, and this expression is usually linked to poor prognosis. Missense mutation in this gene results in the autosomal dominant disorder called Missouri type of human spondyloepimetaphyseal dysplasia (SEMDMO), which is characterized by abnormal growth and modeling of vertebrae and long bones.
Physical form
In 50 mM Tris-HCl, pH 7; 250 mM NaCl; 5 mM CaCl2; 1 mM ZnCl2
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 3
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Yiwen You et al.
Cancer science, 106(12), 1669-1677 (2015-09-13)
Nasopharyngeal cancer (NPC) is an endemic type of head and neck cancer with a high rate of cervical lymph node metastasis. Metastasis is the major cause of death in NPC patients. Increasing evidence indicates that exosomes play a pivotal role
A Matrix Metalloproteinase Gene Expressed in Human T Lymphocytes is identical with Collagenase 3 from Breast Carcinomas.
Willmroth, Frank, et al.
Immunobiol., 198, 375-384 (1998)
M F Leeman et al.
Journal of clinical pathology, 55(10), 758-762 (2002-10-02)
The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes collectively capable of degrading all extracellular matrix components, in particular fibrillar collagen. The importance of this group of proteins in the processes of tumour invasion and metastasis is now widely
Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas.
Freije JM, et al.
The Journal of Biological Chemistry, 269(24), 16766-16773 (1994)
Matrix metalloproteinase 13 activity is associated with poor prognosis in colorectal cancer.
Leeman MF, et al.
Journal of Clinical Pathology, 55(10), 758-762 (2002)
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