SRP6448
Fas Ligand/FasL human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
别名:
ALPS1B, APT1LG1, CD178, CD95-L, CD95L, FASL, FASLG, Fas ligand, TNFSF6
生物来源
human
重组
expressed in HEK 293 cells
标签
6-His tagged (N-terminus)
方案
≥95% (SDS-PAGE)
表单
lyophilized
分子量
calculated mol wt 17.7 kDa
observed mol wt 25-32 kDa by SDS-PAGE (reducing) (His is the predicted N-terminal .)
包装
pkg of 10 μg
杂质
<1 EU/μg endotoxin (LAL test)
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... FASLG(356)
一般描述
Fas ligand also known as FasL, CD178, CD95L, or TNFSF6, is a 40 kDa homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. The FASL gene was mapped to human chromosome 1q24.3. It spans a length of 8 kb and contains 4 exons. It is found to be expressed on T and NK cells that are activated.
生化/生理作用
The binding of Fas ligand to its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Its functions include T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lympho proliferative syndrome (ALPS), a childhood disorder of apoptosis.
外形
Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH 7.0. Normally Mannitol or Trehalose is added as protectants before lyophilization.
制备说明
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Insights into the molecular regulation of FasL (CD178) biology.
Lettau M, et al.
European Journal of Cell Biology, 90(6-7), 456-466 (2011)
Metalloproteinase-mediated release of human Fas ligand.
Kayagaki N, et al.
The Journal of Experimental Medicine, 182(6), 1777-1783 (1995)
Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls.
Fortune M D, et al.
Nature Genetics, 47(7), 839-839 (2015)
Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome.
Fisher G H, et al.
Cell, 81(6), 935-946 (1995)
T Takahashi et al.
International immunology, 6(10), 1567-1574 (1994-10-01)
Fas ligand (FasL) is a 40 kDa type II membrane protein belonging to the tumor necrosis factor family, which induces apoptosis by binding to its receptor, Fas. In this report, we isolated the chromosomal gene for human FasL. The human
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