T0202
Tocainide 盐酸盐
≥98% (HPLC), sodium channel blocker, solid
别名:
2-Amino-N-(2,6-dimethylphenyl)propanamide 盐酸盐
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C11H16N2O · HCl
化学文摘社编号:
分子量:
228.72
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
275-361-2
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated, under inert gas
产品名称
Tocainide 盐酸盐, ≥98% (HPLC), solid
Quality Segment
assay
≥98% (HPLC)
form
solid
storage condition
desiccated, under inert gas
color
white
solubility
DMSO: >20 mg/mL, H2O: ≥5 mg/mL
originator
AstraZeneca
storage temp.
2-8°C
SMILES string
Cl[H].CC(N)C(=O)Nc1c(C)cccc1C
InChI
1S/C11H16N2O.ClH/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12;/h4-6,9H,12H2,1-3H3,(H,13,14);1H
InChI key
AMZACPWEJDQXGW-UHFFFAOYSA-N
Gene Information
Application
Tocainide hydrochloride may be used in cell signaling studies.
Biochem/physiol Actions
Tocainide hydrochloride is a primary amine analog of lidocaine (lignocaine), used for the treatment of tinnitus. It blocks the sodium channels in the pain-producing foci in the nerve membranes and renders an analgesic effect in trigeminal neuralgia.
Tocainide hydrochloride is a sodium channel blocker; Class IB antiarrhythmic.
Features and Benefits
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Tocainide is voltage-dependent and use-dependent sodium channel blocker (class IB type antiarrhythmic); Ki = 115 μM in blockade of inactivated-state sodium channels; IC50 = 985μM in blockade of Na+ currents at a holding potential (HP) of -140 mV; IC50 = 254 μM in blockade of Na+ currents at HP -70 mV; IC50 = 523 μM in blockade of Na+ currents at tonic block (-100 mV); IC50 = 248 μM for use-dependent block at 10 Hz.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves