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Merck
CN

T0266

Sigma-Aldrich

牛磺酸脱氧胆酸钠

别名:

3α,7β-二羟基-5β-胆烷-24-羧酸-N-（2-磺乙基）酰胺, 牛磺熊去氧胆酸 钠盐

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关于此项目

线性分子式:
C26H44NO6SNa
CAS Number:
35807-85-3
分子量:
521.69
MDL编号:
MFCD00065451
UNSPSC代码:
12161900
PubChem化学物质编号:
24899875
NACRES:
NA.25

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描述

anionic

质量水平

200

方案

≥95.0% (TLC)

表单

powder

分子量

521.69 g/mol

CMC

4

HLB

20.1

应用

(Cell Biology, Drug formulation)

SMILES字符串

[H][C@@]12[C@]([C@](CC[C@@H](O)C3)(C)[C@]3([H])C[C@@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC(NCCS(=O)([O-])=O)=O.[Na+]

InChI

1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,22+,24+,25+,26-/m1/s1

InChI key

BHTRKEVKTKCXOH-LBSADWJPSA-N

相关类别

一般描述

牛磺熊去氧胆酸钠是一种胆汁盐，天然存在于小肠中。

应用

牛磺熊去氧胆酸钠已被用于评估ER应激是否与棕榈酸上调（PA）有关。 它还被用于研究其对雌性大鼠雌二醇-17β-D-葡糖苷酸（E-17G）诱导的胆汁淤积的影响。

储存分类代码

11 - Combustible Solids

WGK

WGK 2

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000467773
0000467772
0000467772
0000467773
0000442361

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Structure-function analysis of the tertiary bile acid TUDCA for the resolution of endoplasmic reticulum stress in intestinal epithelial cells
Berger, E. and D. Haller
Biochemical and Biophysical Research Communications, 409, 6-6 (2011)
Masato Mochizuki et al.
PloS one, 13(8), e0202962-e0202962 (2018-08-28)
Cumulus-free in vitro maturation (IVM) provides a powerful tool to manipulate immature oocytes, but IVM oocytes lead to poor development after fertilization. Supplementation of the culture medium with tauroursodeoxycholic acid (TUDCA), a bile acid, has been reported to improve the
Ana F Nunes et al.
Molecular neurobiology, 45(3), 440-454 (2012-03-23)
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by accumulation of amyloid-β (Aβ) peptide in the hippocampus and frontal cortex of the brain, leading to progressive cognitive decline. The endogenous bile acid tauroursodeoxycholic acid (TUDCA) is a strong neuroprotective agent
S Kinbara et al.
Scandinavian journal of gastroenterology, 32(9), 947-952 (1997-09-23)
Estradiol-17 beta-D-glucuronide (E-17G), a metabolite of natural estrogen, is well known to cause intrahepatic cholestasis in humans. We therefore investigated the effect of sodium tauroursodeoxycholate (T-UDCA), on E-17G-induced cholestasis in female rats. For the evaluation of the drug, animals given
Sabine Schulz et al.
Biochimica et biophysica acta, 1828(9), 2121-2133 (2013-05-21)
The cell-toxic bile salt glycochenodeoxycholic acid (GCDCA) and taurochenodeoxycholic acid (TCDCA) are responsible for hepatocyte demise in cholestatic liver diseases, while tauroursodeoxycholic acid (TUDCA) is regarded hepatoprotective. We demonstrate the direct mitochondrio-toxicity of bile salts which deplete the mitochondrial membrane
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HPLC Separation of Bile Acids with Ascentis Express C18

Investigate bile acid roles in gut hormone profiles and glycemic control, vital for clinical labs exploring potential mechanisms.

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